URV Institutional Repository
Español Català English
Title
Long-term supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet-induced obese rats - PC:1167
Author, as appears in the article.Bladé, C.
Author, as appears in the article.Arola-Arnal, A.
Author, as appears in the article.Arola, L.
Author, as appears in the article. Salvadó, M.J.
Author, as appears in the article.Casanova, E.,
Author, as appears in the article.Ribas-Latre, A.,
Author, as appears in the article.Pascual-Serrano, A.
Author, as appears in the article.Baselga-Escudero, L.
AbstractDeregulation of miR-33 and miR-122, as major regulators of lipid metabolism in liver, has been related to obesity and metabolic syndrome. Proanthocyanidins repress these microRNAs in healthy animals. Hence, we hypothesized that long-term consumption of dietary proanthocyanidins can normalize the expression of miR-33a and miR-122. Therefore, the objective of this work was to determine whether the long-term consumption of proanthocyanidins could effectively normalize the expression of miR-33a and miR-122 in rats made obese by a high-fat diet and to determine the effective dose. Rats were maintained on the high-fat diet with or without supplementation with a grape seed proanthocyanidin extract at low, medium, or high dose in relation to human consumption. Results show that 3 weeks of supplementation with grape seed proanthocyanidin extract normalized the overexpression of miR-33a and miR-122 in obese rats' liver for all doses studied, with no dose-dependent outcome, and also reduced the levels of plasma and liver lipids in a dose-dependent manner. In conclusion, a low sustained dose of proanthocyanidins, lower than the estimated mean intake for a European population, is enough to normalize miR-33a and miR-122 levels in the livers of obese rats. Therefore, a proanthocyanidin-rich diet during obesity can improve some of the metabolic syndrome symptoms at least at the molecular level. © 2015 Elsevier Inc.
ISSN0271-5317
Journal volume35
First page337
Last page345
Link to the orginal sourcehttp://dx.doi.org/10.1016/j.nutres.2015.02.008
Publication TypeArticle
Publication TypeArtículo
Publication TypeArticle
EntityUniversitat Rovira i Virgili
DepartmentDepartament de Bioquímica i Biotecnologia
Research groupGrup de Recerca en Nutrigenòmica
Document URLhttp://nportal0.urv.cat:18080/fourrepo/rest/digitalobjects/DS?objectId=PC%3A1167&datastreamId=DocumentPrincipal&mime=application%2Fpdf
Document nameLong-term supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet-induced obese rats
Source publication titleNutrition Research
AuthorBLADÉ SEGARRA, MARIA CINTA
AuthorAROLA ARNAL, ANNA
AuthorAROLA FERRER, LUIS MARIA
AuthorSALVADÓ ROVIRA, MARIA JOSEPA
AuthorCASANOVA VALLVÉ, ESTER
AuthorRIBAS LATRE, ALEIX
AuthorPASCUAL SERRANO, AÏDA
AuthorBASELGA ESCUDERO, LAURA
Thematic AreasBiochemistry and technology
Thematic AreasBioquímica y tecnología
Thematic AreasBioquímica i biotecnologia
KeywordsFlavonoids
KeywordsFas
KeywordsAbca1
Subject matterFlavonoides -- Efectes fisiològics
Subject matterProantocianidines
Subject matterObesitat -- Aspectes nutritius
Journal publication year2015
Researcher identifier0000-0003-2838-2402
Researcher identifier0000-0001-6529-1345
Researcher identifier0000-0003-2767-1974
Researcher identifier0000-0003-3883-3326
Researcher identifiern/a
Researcher identifiern/a
Researcher identifiern/a
Researcher identifiern/a
Search your registry in
Available files
DocumentPrincipal

Information

© 2016 Universitat Rovira i Virgili