Articles producció científica> Química Física i Inorgànica

Designing new readily available sugar-based ligands for asymmetric transfer hydrogenation of ketones. In the quest to expand the substrate scope

  • Identification data

    Identifier: PC:2570
    Handle: http://hdl.handle.net/20.500.11797/PC2570
  • Authors:

    Oscar Pàmies
    Jèssica Margalef
    Montserrat Diéguez
  • Others:

    Author, as appears in the article.: Oscar Pàmies; Jèssica Margalef; Montserrat Diéguez
    Department: Química Física i Inorgànica
    URV's Author/s: PAMIES OLLÉ, OSCAR; Jèssica Margalef; DIÉGUEZ FERNÁNDEZ, MONTSERRAT
    Keywords: asymmetric transfer hydrogenation ketones sugar-based ligands
    Abstract: Asymmetric transfer hydrogenation (ATH) has emerged as one of the most effective and sustainable synthetic tool for synthesizing enantiopure alcohols. Since Noyori’s group successfully applied Ru-catalysts modified with chiral b-amino alcohols or diamines as ligands, a large number of catalytic systems has been successfully developed. However, further improvement in terms of substrate scope, selectivity, and turnover frequency are required to make the process competitive with conventional hydrogenations. Overcoming these limitations requires research toward the design of new ligands. Such a task becomes easier if readily modulable chiral ligands are at hand. Sugar-based ligands are particularly useful for addressing this need. They are readily available, highly functionalized, and their modular constructions are easy. Series of chiral ligands can be screened in the search for high activities and selectivities for each type of substrate. This digest paper will discuss the progress on the use of sugar-based ligands in ATH reactions.
    Research group: Organometàl.lics i Catàlisi Homogènia
    Thematic Areas: Química Química Chemistry
    licence for use: thttps://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0040-4039
    Author identifier: 0000-0002-2352-8508; n/a; 0000-0002-8450-0656
    Record's date: 2017-02-22
    Last page: 1308
    Journal volume: 57
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0040403916301320
    Article's DOI: https://doi.org/10.1016/j.tetlet.2016.02.022
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    First page: 1301
    Publication Type: Post-print
  • Keywords:

    Biochemistry; Chemistry; Organic; Drug Discovery; Organic Chemistry
    asymmetric transfer hydrogenation
    ketones
    sugar-based ligands
    Química
    Química
    Chemistry
    0040-4039
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