Articles producció científica> Medicina i Cirurgia

Nutrients in energy and one-carbon metabolism: Learning from metformin users

  • Identification data

    Identifier: PC:2585
    Handle: http://hdl.handle.net/20.500.11797/PC2585
  • Authors:

    Camps, J.
    Luciano-Mateo, F.
    Hernández-Aguilera, A.
    Cabre, N.
    Fernández-Arroyo, S.
    Lopez-Miranda, J.
    Menendez, J.A.
    Joven, J.
  • Others:

    Author, as appears in the article.: Camps, J.; Luciano-Mateo, F.; Hernández-Aguilera, A.; Cabre, N.; Fernández-Arroyo, S.; Lopez-Miranda, J.; Menendez, J.A.; Joven, J.
    Department: Medicina i Cirurgia
    URV's Author/s: CAMPS ANDREU, JORGE; Luciano-Mateo, F.; Hernández-Aguilera, A.; Cabre, N.; Fernández-Arroyo, S.; Lopez-Miranda, J.; Menendez, J.A.; JOVEN MARIED, JORGE
    Keywords: obesity Energy intake Diabetes mellitus
    Abstract: Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive intake of nutrients and drugs mimicking dietary effects and dietary restriction are the most successful manipulations targeting age-related pathways. Phenotypic heterogeneity and individual response to metabolic stressors are closely related food intake. Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially the way in which organismal bioenergetics remodel one-carbon metabolism. Metformin not only inhibits mitochondrial complex 1, modulating the metabolic response to nutrient intake, but also alters one-carbon metabolic pathways. Here, we discuss findings on the mechanism(s) of action of metformin with the potential for therapeutic interpretations.
    Research group: Unitat de Recerca Biomèdica
    Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 2072-6643
    Author identifier: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Record's date: 2017-03-06
    Journal volume: 9
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/9/2/121
    Article's DOI: 10.3390/nu9020121
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    First page: Art.num. 121
    Publication Type: Article Artículo Article
  • Keywords:

    Metabolisme energètic
    Obesitat
    Diabetis
    obesity
    Energy intake
    Diabetes mellitus
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    2072-6643
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