Articles producció científica> Bioquímica i Biotecnologia

Phosphotyrosine phosphatase R3 receptors: Origin, evolution and structural diversification

  • Identification data

    Identifier: PC:2677
    Handle: http://hdl.handle.net/20.500.11797/PC2677
  • Authors:

    Garcia-España, A
    Chicote, J.U.
    DeSalle, R.
  • Others:

    Author, as appears in the article.: Garcia-España, A; Chicote, J.U.; DeSalle, R.
    Department: Bioquímica i Biotecnologia
    URV's Author/s: GARCIA-ESPAÑA MONSONÍS, ANTONIO ENRIQUE; Chicote, J.U.; DeSalle, R.
    Keywords: Està en blanc
    Abstract: Limited data exists on the interrelationships between physical activity (PA), sedentary behaviors and sleep concerning cardiometabolic risk factors in aged adults at high cardiovascular disease risk. Our aim was to examine independent and joint associations between time spent in leisure-time PA, sedentary behaviors and sleep on the prevalence of obesity, type 2 diabetes (T2D) and components of the metabolic syndrome (MetS) in Mediterranean individuals at high cardiovascular risk. Cross-sectional analyses were performed on baseline data from 5776 Spanish adults (aged 55-75y in men; 60-75y in women) with overweight/ obesity and MetS, from October 2013 to October 2016, in the PREDIMED-PLUS trial. Employing multivariable-adjusted Cox regression with robust variance and constant time (given the cross-sectional design), higher prevalence of obesity, T2D and abdominal obesity as component of the MetS were associated with greater time in TV-viewing (Relative Risk, RR: 1.02, 95%CI: 1.01, 1.03; RR:1.04, 95%CI: 1.02, 1.06 and RR: 1.01 95%CI: 1.00, 1.02; respectively, all P < .01). Conversely, greater time in moderate-vigorous PA (MVPA) was associated with lower prevalence of obesity, T2D, abdominal obesity and low HDL-cholesterol (RR: 0.95, 95%CI: 0.93, 0.97; RR: 0.94, 95%CI: 0.89, 0.99; RR: 0.97, 95%CI: 0.96, 0.98; and RR: 0.95, 95%CI: 0.91, 0.99, respectively, all P < .05). For these outcomes, theoretically substituting 1-h/day of MVPA for 1-h/day TV-viewing was also significantly associated with lower prevalence (RR 0.91 to 0.97, all P < .05). Similar lower RR in these outcomes was observed when substituting 1-h/day of MVPA for 1-h/day of sleeping. Longer time watching TV and not meeting MVPA recommendations were jointly associated with higher RR of the prevalence of obesity and T2D. We concluded that, in senior individuals at high cardiovascular risk, greater time spent on MVPA and fewer on sedentary behaviors was inversely associated with prevalence of obesity, T2D, and some of the components of MetS.
    Research group: Grup de Recerca Biomèdica HJ23
    Thematic Areas: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1932-6203
    Author identifier: ; N/D; N/D
    Record's date: 2017-03-21
    Journal volume: 12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172887
    Article's DOI: https://doi.org/10.1371/journal.pone.0172887
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    First page: e0172887
    Publication Type: Article Artículo Article
  • Keywords:

    Proteïna-tirosina-fosfatasa
    Està en blanc
    Biochemistry and technology
    Bioquímica y tecnología
    Bioquímica i biotecnologia
    1932-6203
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