Author, as appears in the article.: Simó, J.M.; Gallifa, I.F.; Aguilera, A.H.; Heredia, A.G.; Cabré, N.; Mateo, F.L.; Paredero, V.M.; Camps, J.; Joven, J.

Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia

URV's Author/s: SIMÓ SISÓ, JOSÉ MARIA; Gallifa, I.F.; Aguilera, A.H.; Heredia, A.G.; Cabré, N.; Mateo, F.L.; MARTÍN PAREDERO, VICENTE; CAMPS ANDREU, JORGE; JOVEN MARIED, JORGE

Keywords: Galectin-3 F2-isoprostanes atherosclerosis

Abstract: Galectin-3 is a modulator of oxidative stress, inflammation, and fibrogenesis involved in the pathogenesis of vascular diseases. The present study sought to characterize, in patients with peripheral artery disease (PAD), the localization of galectin-3 in arterial tissue, and to analyze the relationships between the circulating levels of galectin-3 and oxidative stress and inflammation. It also sought to compare the diagnostic accuracy of galectin-3 with that of other biochemical markers of this disease. We analyzed femoral or popliteal arteries from 50 PAD patients, and four control arteries. Plasma from 86 patients was compared with that from 72 control subjects. We observed differences in the expression of galectin-3 in normal arteries, and arteries from patients with PAD, with a displacement of the expression from the adventitia to the media, and the intima. In addition, plasma galectin-3 concentration was increased in PAD patients, and correlated with serologic markers of oxidative stress (F2-isoprostanes), and inflammation [chemokine (C–C motif) ligand 2, C-reactive protein, β-2-microglobulin]. We conclude that the determination of galectin-3 has good diagnostic accuracy in the assessment of PAD and compares well with other analytical parameters currently in use.

Research group: Unitat de Recerca Biomèdica

Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1661-6596

Author identifier: ; ; ; ; ; ; 0000-0002-2740-5847; ; 0000-0003-2749-4541

Record's date: 2017-05-26

Journal volume: 18

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: http://www.mdpi.com/1422-0067/18/5/973

Funding program: european; FEDER; PI15/00285 european; FEDER; PI11/00130 european; FEDER; PI11/02817

Article's DOI: 10.3390/ijms18050973

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

First page: 973

Publication Type: Article Artículo Article