Author, as appears in the article.: Salas-Salvadó, J.; Casas, R.; Urpi-Sardà, M.; Sacanella, E.; Arranz, S.; Corella, D.; Castañer, O.; Lamuela-Raventós, R.; Lapetra, J.; Portillo, M.; Estruch, R.

Department: Bioquímica i Biotecnologia

URV's Author/s: SALAS SALVADÓ, JORGE; Casas, R.; Urpi-Sardà, M.; Sacanella, E.; Arranz, S.; Corella, D.; Castañer, O.; Lamuela-Raventós, R.; Lapetra, J.; Portillo, M.; Estruch, R.

Abstract: Objective. To evaluate the long-Term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®. Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β (P<0.05; all) compared to LFD. IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P<0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P<0.05; both) in the MeDiet+nuts group. Conclusions. Long-Term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.

Research group: Alimentació, Nutrició, Creixement i Salut Mental

Thematic Areas: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0962-9351

Author identifier: 0000-0003-2700-7459; ; ; ; ; ; ; ; ; ;

Record's date: 2017-09-14

Journal volume: 2017

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.hindawi.com/journals/mi/2017/3674390/

Funding program: altres; RyC; PI13/02184

Article's DOI: 10.1155/2017/3674390

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

First page: 3674390

Publication Type: Article Artículo Article