Author, as appears in the article.: Vidal, F.; Rosado-Sánchez, I.; Herrero-Fernández, I.; Álvarez-Ríos, A.I.; Genebat, M. ; Abad-Carrillo, M.A.; Ruiz-Mateos, E.; Pulido, F.; González-García, J.; Montero, M.; Bernal-Morell, E.; Leal, M.; Pacheco, Y.M.

Department: Medicina i Cirurgia

URV's Author/s: VIDAL MARSAL, FRANCISCO; Rosado-Sánchez, I.; Herrero-Fernández, I.; Álvarez-Ríos, A.I.; Genebat, M. ; Abad-Carrillo, M.A.; Ruiz-Mateos, E.; Pulido, F.; González-García, J.; Montero, M.; Bernal-Morell, E.; Leal, M.; Pacheco, Y.M.

Keywords: Delayed cART CD4/CD8 ratio antiretroviral therapy

Abstract: We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.

Research group: Grup de Recerca Biomèdica HJ23

Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0066-4804

Author identifier: 0000-0002-6692-6186

Record's date: 2017-11-30

Journal volume: 61

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://aac.asm.org/content/61/8/e00605-17.long

Funding program: plan; Ministerio de Sanidad, Servicios Sociales e Igualdad; ISCIII; RD12/0017/0037 altres; Instituto de Salud Carlos III; ISCIII; RD12/0017/0018 plan; Ministerio de Sanidad, Servicios Sociales e Igualdad; ISCIII; RD06/0006/0035 altres; Instituto de Salud Carlos III; ISCIII; PI14/01693 altres; Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía; FEDER; CTS2593

Article's DOI: 10.1128/AAC.00605-17

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

First page: e00605

Publication Type: Article Artículo Article