Author, as appears in the article.: Borrull, F. ; Salas, D. ; Fontanals, N. ; Marcé, R. M.

Department: Química Analítica i Química Orgànica

URV's Author/s: BORRULL BALLARÍN, FRANCESC; Salas, D. ; Fontanals, N. ; MARCÉ RECASENS, ROSA MARIA

Keywords: Cationic mixed-mode solid-phase extraction Anionicmixed-mode solid-phase extraction High-resolutionmass spectrometry

Abstract: The aim of the present study is to broaden the applications of mixed-mode ion-exchange solid-phase extraction sorbents to extract both basic and acidic compounds simultaneously by combining the sorbents in a single cartridge and developing a simplified extraction procedure. Four different cartridges containing negative and positive charges in the same configuration were evaluated and compared to extract a group of basic, neutral, and acidic pharmaceuticals selected as model compounds. After a thorough optimization of the extraction conditions, the four different cartridges showed to be capable of retaining basic and acidic pharmaceuticals simultaneously through ionic interactions, allowing the introduction of a washing step with 15 mL methanol to eliminate interferences retained by hydrophobic interactions. Using the best combined cartridge, a method was developed, validated, and further applied to environmental waters to demonstrate that the method is promising for the extraction of basic and acidic compounds from very complex samples.

Research group: Grup de Cromatografia. Aplicacions Mediambientals

Thematic Areas: Química Química Chemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1618-2642

Author identifier: 0000-0003-2718-9336; ; ; 0000-0002-5667-2899

Record's date: 2018-03-01

Last page: 469

Journal volume: 410

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://link.springer.com/article/10.1007/s00216-017-0736-5

Funding program: plan; Excelencia; CTQ2014-52617-P plan; PhD fellowship; BES-2012-057792

Article's DOI: 10.1007/s00216-017-0736-5

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

First page: 459

Publication Type: Article Artículo Article