Author, as appears in the article.: JORDI SALAS-SALVADO; MONICA BULLO; NANCY BABIO; MIGUEL ANGEL MARTINEZ-GONZALEZ; NURIA IBARROLA-JURADO; JOSEP BASORA; RAMON ESTRUCH; MARIA ISABEL COVAS; DOLORES CORELLA; FERNANDO AROS; VALENTINA RUIZ-GUTIERREZ; EMILIO ROS; PREDIMED STUDY INVESTIGATORS

Department: Bioquímica i Biotecnologia

URV's Author/s: SALAS SALVADÓ, JORGE; BULLÓ BONET, MÒNICA; BABIO SÁNCHEZ, NANCY ELVIRA; MIGUEL ANGEL MARTINEZ-GONZALEZ; NURIA IBARROLA-JURADO; JOSEP BASORA; RAMON ESTRUCH; MARIA ISABEL COVAS; DOLORES CORELLA; FERNANDO AROS; VALENTINA RUIZ-GUTIERREZ; EMILIO ROS; PREDIMED STUDY INVESTIGATORS

Keywords: Type-2 diabetes Mediterranean diet Randomized trial

Abstract: OBJECTIVE: To test the effects of two Mediterranean diet (MedDiet) interventions versus a low-fat diet on incidence of diabetes. RESEARCH DESIGN AND METHODS: This was a three-arm randomized trial in 418 nondiabetic subjects aged 55-80 years recruited in one center (PREDIMED-Reus, northeastern Spain) of the Prevención con Dieta Mediterránea [PREDIMED] study, a large nutrition intervention trial for primary cardiovascular prevention in individuals at high cardiovascular risk. Participants were randomly assigned to education on a low-fat diet (control group) or to one of two MedDiets, supplemented with either free virgin olive oil (1 liter/week) or nuts (30 g/day). Diets were ad libitum, and no advice on physical activity was given. The main outcome was diabetes incidence diagnosed by the 2009 American Diabetes Association criteria. RESULTS: After a median follow-up of 4.0 years, diabetes incidence was 10.1% (95% CI 5.1-15.1), 11.0% (5.9-16.1), and 17.9% (11.4-24.4) in the MedDiet with olive oil group, the MedDiet with nuts group, and the control group, respectively. Multivariable adjusted hazard ratios of diabetes were 0.49 (0.25-0.97) and 0.48 (0.24-0.96) in the MedDiet supplemented with olive oil and nuts groups, respectively, compared with the control group. When the two MedDiet groups were pooled and compared with the control group, diabetes incidence was reduced by 52% (27-86). In all study arms, increased adherence to the MedDiet was inversely associated with diabetes incidence. Diabetes risk reduction occurred in the absence of significant changes in body weight or physical activity. CONCLUSIONS: MedDiets without calorie restriction seem to be effective in the prevention of diabetes in subjects at high cardiovascular risk.

Research group: Alimentació, Nutrició, Creixement i Salut Mental

Thematic Areas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0149-5992

Record's date: 2016-06-14

Last page: 19

Journal volume: 34

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: http://care.diabetesjournals.org/content/34/1/14

Article's DOI: 10.2337/dc10-1288

Entity: Universitat Rovira i Virgili

Journal publication year: 2011

First page: 14

Publication Type: Article Artículo Article