Author, as appears in the article.: Babio, N.; Barrubés, L.; Mena-Sánchez, G.; Toledo, E.; Ramírez-Sabio, JB.; Estruch, R.; Ros, E.; Fitó, M.; Arós, F.; Santos-Lozano, JM.; Serra-Majem, L.; Pintó, X.; Martínez-González, MÁ.; Sorlí, JV, ; Basora, J.; Salas-Salvadó, J.

Department: Bioquímica i Biotecnologia

URV's Author/s: BABIO SÁNCHEZ, NANCY ELVIRA; Barrubés, L.; Mena-Sánchez, G.; Toledo, E.; Ramírez-Sabio, JB.; Estruch, R.; Ros, E.; Fitó, M.; Arós, F.; Santos-Lozano, JM.; Serra-Majem, L.; Pintó, X.; Martínez-González, MÁ.; Sorlí, JV, ; Basora, J.; SALAS SALVADÓ, JORGE

Abstract: Prospective studies have reported an inverse association between the consumption of total dairy products and milk and the risk of colorectal cancer (CRC). Nonetheless, there is little and inconsistent evidence regarding subtypes of dairy product and CRC risk. We assessed the associations between the consumption of total dairy products, their different subtypes and CRC risk in older Mediterranean individuals at high cardiovascular risk. We analyzed data from 7,216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Individuals were recruited between 2003 and 2009 and followed up until December 2012. At baseline and yearly thereafter, consumption of total and specific dairy products was assessed using a validated 137-item food-frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC incidence were estimated for tertiles of mean consumption of dairy products during the follow-up. During a median [interquartile range] follow-up of 6.0 [4.4-7.3] years, we documented 101 incident CRC cases. In the multivariable-adjusted models, HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme tertiles of total dairy product and low-fat milk consumption were 0.55 (95% CI: 0.31-0.99; p-trend = 0.037) and 0.54 (95% CI: 0.32-0.92; p-trend = 0.022), respectively. No significant associations with other dairy products (whole-fat and low-fat dairy products; total, low-fat and whole-fat yogurt; cheese; total, low-fat and whole-fat milk; concentrated full-fat dairy products, sugar-enriched dairy products and fermented dairy products) were found. A high consumption of total dairy products and low-fat milk was significantly associated with a reduced CRC risk.

Research group: Alimentació, Nutrició, Creixement i Salut Mental

Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0020-7136

Author identifier: 0000-0003-3527-5277; ; ; ; ; ; ; ; ; ; ; ; ; ; ; 0000-0003-2700-7459

Record's date: 2018-06-25

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.31540

Article's DOI: 10.1002/ijc.31540

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Article Artículo Article