Author, as appears in the article.: Salas-Salvadó, J.; Medina-Remón, A.; Casas, R.; Tressserra-Rimbau, A.; Ros, E.; Martínez-González, MA.; Fitó, M.; Corella, D.; Lamuela-Raventos, RM.; Estruch, R.

Department: Bioquímica i Biotecnologia

URV's Author/s: SALAS SALVADÓ, JORGE; Medina-Remón, A.; Casas, R.; Tressserra-Rimbau, A.; Ros, E.; Martínez-González, MA.; Fitó, M.; Corella, D.; Lamuela-Raventos, RM.; Estruch, R.

Keywords: Folin-Ciocalteu Mediterranean diet Blood pressure

Abstract: High dietary polyphenol intake is associated with reduced all-cause mortality and a lower incidence of cardiovascular events. However, the mechanisms involved are not fully understood. The aim of the present substudy of the PREvención con DIetaMEDiterránea (Prevention with Mediterranean diet; PREDIMED) trial was to analyse the relationship between polyphenol intake measured by total urinary polyphenol excretion (TPE), and circulating inflammatory biomarkers and cardiovascular risk factors in elderly individuals. A substudy of 1139 high-risk participants was carried out within the PREDIMED trial. The subjects were randomly assigned to a low-fat control diet or to two Mediterranean diets, supplemented with either extra-virgin olive oil or nuts. Dietary intake, anthropometric data, clinical and laboratory assessments, including inflammatory biomarkers, and urinary TPE were measured at baseline and after the one-year intervention. Participants in the highest tertile of changes in urinary TPE (T3) showed significantly lower plasma levels of inflammatory biomarkers [vascular cell adhesion molecule 1 (VCAM-1) (-9.47 ng ml-1 ), intercellular adhesion molecule 1 (-14.71 ng ml-1 ), interleukin 6 (-1.21 pg ml-1 ), tumour necrosis factor alpha (-7.05 pg ml-1 ) and monocyte chemotactic protein 1 (-3.36 pg ml-1 )] than those inthe lowest tertile (T1, P < 0.02; all). A significant inverse correlation existed between urinary TPE and the plasma concentration of\VCAM-1 (r = -0.301; P < 0.001). In addition, systolic and diastolic blood pressure (BP) decreased and plasma high-density lipoprotein cholesterol increased in parallel with increasing urinary TPE (T3 vs. T1) (P < 0.005 and P = 0.004, respectively). Increases in polyphenol intake measured as urinary TPE are associated with decreased inflammatory biomarkers, suggesting a dose-dependent anti-inflammatory effect of polyphenols. In addition, high polyphenol intake improves cardiovascular risk factors- mainly BP and the lipid profile

Research group: Alimentació, Nutrició, Creixement i Salut Mental

Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0306-5251

Author identifier: 0000-0003-2700-7459; ; ; ; ; ; ; ; ;

Record's date: 2018-06-26

Last page: 128

Journal volume: 83

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.12986

Article's DOI: 10.1111/bcp.12986

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

First page: 114

Publication Type: Article Artículo Article