Author, as appears in the article.: Fernández-Cao JC, Arija V, Aranda N, Basora J, Diez-Espino J, Estruch R, Fitó M, Corella D, Salas-Salvadó J

Department: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia Medicina i Cirurgia

URV's Author/s: ARIJA VAL, MARIA VICTORIA ; ARANDA PONS, NÚRIA; BASORA GALLISA, JOSEP ; SALAS SALVADÓ, JORGE

Keywords: PREDIMED obesity Type 2 Diabetes

Abstract: BACKGROUND: Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese individuals. Therefore, the aim of this study was to assess the relationship between sTfR and the risk of T2DM in obese and nonobese subjects. DESIGN: A nested case-control study of 153 cases of newly diagnosed diabetic subjects, 73 obese and 80 nonobese, and 306 individually matched controls, 138 obese and 166 nonobese, who did not develop T2DM for a median 6-year follow-up (interquartile range: 3·9-6·5) was conducted using data from the PREvention with MEDiterranean Diet (PREDIMED) cohort (http://www.controlled-trials.com/ISRCTN35739639). Cases and controls were matched for age (≤ 67 vs. > 67 years), gender, dietary intervention group and BMI (≤ 27 vs. > 27 kg/m2 ). RESULTS: Waist circumference is the main determinant of sTfR concentrations in the whole sample (β = 0·476, P < 0·001), in the obese (β = 0·802, P < 0·001) and the nonobese (β = 0·455, P = 0·003). Furthermore, sTfR is directly associated with the risk of T2DM in obese individuals (OR = 2·79; 95% CI: 1·35-5·77, P = 0·005) and inversely associated in nonobese individuals (OR = 0·40; 95% CI: 0·20-0·79, P = 0·015). CONCLUSIONS: The association between sTfR levels and risk of T2DM in a population at high cardiovascular risk depend on the presence or absence of obesity. While in nonobese subjects elevated sTfR levels are associated with a decreased risk of developing T2DM, in obese subjects the risk increases. This suggests that obesity alters the relationship between sTfR and T2DM incidence.

Research group: Alimentació, Nutrició, Creixement i Salut Mental Nutrició i Salut Mental

Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0014-2972

Author identifier: 0000-0002-1758-0975; ; 0000-0001-9708-747X; ; ; ; ; ; 0000-0003-2700-7459

Record's date: 2018-06-26

Last page: 230

Journal volume: 47

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.12725

Article's DOI: 10.1111/eci.12725

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

First page: 221

Publication Type: Article Artículo Article