Articles producció científica> Medicina i Cirurgia

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation

  • Identification data

    Identifier: imarina:1842471
    Handle: http://hdl.handle.net/20.500.11797/imarina1842471
  • Authors:

    Malandrino MI, Fucho R, Weber M, Calderon-Dominguez M, Mir JF, Valcarcel L, Escoté X, Gómez-Serrano M, Peral B, Salvadó L, Fernández-Veledo S, Casals N, Vázquez-Carrera M, Villarroya F, Vendrell JJ, Serra D, Herrero L.
  • Others:

    Author, as appears in the article.: Malandrino MI, Fucho R, Weber M, Calderon-Dominguez M, Mir JF, Valcarcel L, Escoté X, Gómez-Serrano M, Peral B, Salvadó L, Fernández-Veledo S, Casals N, Vázquez-Carrera M, Villarroya F, Vendrell JJ, Serra D, Herrero L.
    Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    URV's Author/s: Fernandez Veledo, Sonia / Vendrell Ortega, Juan José
    Keywords: Type 2 diabetes Obesity Macrophages Inflammation Fatty acid oxidation Cpt1 Adipocytes obesity macrophages inflammation fatty acid oxidation cpt1 adipocytes
    Abstract: Lipid overload in obesity and type 2 diabetes is associated with adipocyte dysfunction, inflammation, macrophage infiltration, and decreased fatty acid oxidation (FAO). Here, we report that the expression of carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme in mitochondrial FAO, is higher in human adipose tissue macrophages than in adipocytes and that it is differentially expressed in visceral vs. subcutaneous adipose tissue in both an obese and a type 2 diabetes cohort. These observations led us to further investigate the potential role of CPT1A in adipocytes and macrophages. We expressed CPT1AM, a permanently active mutant form of CPT1A, in 3T3-L1 CARΔ1 adipocytes and RAW 264.7 macrophages through adenoviral infection. Enhanced FAO in palmitate-incubated adipocytes and macrophages reduced triglyceride content and inflammation, improved insulin sensitivity in adipocytes, and reduced endoplasmic reticulum stress and ROS damage in macrophages. We conclude that increasing FAO in adipocytes and macrophages improves palmitate-induced derangements. This indicates that enhancing FAO in metabolically relevant cells such as adipocytes and macrophages may be a promising strategy for the treatment of chronic inflammatory pathologies such as obesity and type 2 diabetes.Copyright © 2015 the American Physiological Society.
    Thematic Areas: Physiology (medical) Physiology Odontología Nutrição Medicine (all) Medicina ii Medicina i General medicine Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 15221555
    Author's mail: sonia.fernandez@urv.cat juanjose.vendrell@urv.cat
    Author identifier: 0000-0003-2906-3788 0000-0002-6994-6115
    Record's date: 2023-07-31
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://journals.physiology.org/doi/full/10.1152/ajpendo.00362.2014
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: American Journal Of Physiology-Endocrinology And Metabolism. 308 (9): E756-E769
    APA: Malandrino MI, Fucho R, Weber M, Calderon-Dominguez M, Mir JF, Valcarcel L, Escoté X, Gómez-Serrano M, Peral B, Salvadó L, Fernández-Veledo S, Casals (2015). Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation. American Journal Of Physiology-Endocrinology And Metabolism, 308(9), E756-E769. DOI: 10.1152/ajpendo.00362.2014
    Article's DOI: 10.1152/ajpendo.00362.2014
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2015
    Publication Type: Journal Publications
  • Keywords:

    Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Physiology,Physiology (Medical)
    Type 2 diabetes
    Obesity
    Macrophages
    Inflammation
    Fatty acid oxidation
    Cpt1
    Adipocytes
    obesity
    macrophages
    inflammation
    fatty acid oxidation
    cpt1
    adipocytes
    Physiology (medical)
    Physiology
    Odontología
    Nutrição
    Medicine (all)
    Medicina ii
    Medicina i
    General medicine
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
  • Documents:

  • Cerca a google

    Search to google scholar