Author, as appears in the article.: Garcia-Arellano A, Ramallal R, Ruiz-Canela M, Salas-Salvadó J, Corella D, Shivappa N, Schröder H, Hébert JR, Ros E, Gómez-Garcia E, Estruch R, Lapetra J, Arós F, Fiol M, Serra-Majem L, Pintó X, Babio N, González JI, Fitó M, Martínez JA, Martínez-González MA, Predimed Investigators

Department: Bioquímica i Biotecnologia Medicina i Cirurgia

e-ISSN: 2072-6643

URV's Author/s: Babio Sánchez, Nancy Elvira / Basora Gallisa, Josep / Castro Salomó, Antoni / Salas Salvadó, Jorge / Solà Alberich, Rosa Maria

Keywords: Randomized controlled trial Prospective study Predimed study Predimed Outcome assessment Olive oil Nut Multicenter study Middle aged Mediterranean diet Male Low fat diet Inflammation Incidence Human High risk population Heart infarction Heart death Food frequency questionnaire Follow up Female Dietary inflammatory index Diet Cerebrovascular accident Cardiovascular risk Cardiovascular disease Assessment of humans Article Aged Adult predimed dietary inflammatory index cardiovascular disease

Abstract: Previous studies have reported an association between a more pro-inflammatory diet profile and various chronic metabolic diseases. The Dietary Inflammatory Index (DII) was used to assess the inflammatory potential of nutrients and foods in the context of a dietary pattern. We prospectively examined the association between the DII and the incidence of cardiovascular disease (CVD: myocardial infarction, stroke or cardiovascular death) in the PREDIMED (Prevención con Dieta Mediterránea) study including 7216 high-risk participants. The DII was computed based on a validated 137-item food frequency questionnaire. Multivariate-adjusted hazard ratios (HR) and 95% confidence intervals of CVD risk were computed across quartiles of the DII where the lowest (most anti-inflammatory) quartile is the referent. Risk increased across the quartiles (i.e., with increasing inflammatory potential): HR(quartile2) = 1.42 (95%CI = 0.97-2.09); HR(quartile3) = 1.85 (1.27-2.71); and HR(quartile4) = 1.73 (1.15-2.60). When fit as continuous the multiple-adjusted hazard ratio for each additional standard deviation of the DII was 1.22 (1.06-1.40). Our results provide direct prospective evidence that a pro-inflammatory diet is associated with a higher risk of cardiovascular clinical events.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20726643

Author's mail: josep.basora@urv.cat nancy.babio@urv.cat rosa.sola@urv.cat jordi.salas@urv.cat antoni.castro@urv.cat josep.basora@urv.cat

Author identifier: 0000-0003-3527-5277 0000-0002-8359-235X 0000-0003-2700-7459 0000-0001-5441-6333

Last page: 4138

Record's date: 2023-05-21

Journal volume: 7

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/7/6/4124

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 7 (6): 4124-4138

APA: Garcia-Arellano A, Ramallal R, Ruiz-Canela M, Salas-Salvadó J, Corella D, Shivappa N, Schröder H, Hébert JR, Ros E, Gómez-Garcia E, Estruch R, Lapetra (2015). Dietary inflammatory index and incidence of cardiovascular disease in the PREDIMED study. Nutrients, 7(6), 4124-4138. DOI: 10.3390/nu7064124

Article's DOI: 10.3390/nu7064124

Entity: Universitat Rovira i Virgili

Journal publication year: 2015

First page: 4124

Publication Type: Journal Publications