Author, as appears in the article.: Hernández-Aguilera A; Fernández-Arroyo S; Cuyàs E; Luciano-Mateo F; Cabre N; Camps J; Lopez-Miranda J; Menendez J; Joven J

Department: Medicina i Cirurgia

URV's Author/s: Camps Andreu, Jorge / FERNANDEZ ARROYO, SALVADOR / Joven Maried, Jorge

Keywords: Obesity Nutrient toxicity Metabolomics Epigenetics Dna methylation Diabetes nutrient toxicity metabolomics epigenetics dna methylation diabetes

Abstract: We live in a world fascinated by the relationship between disease and nutritional disequilibrium. The subtle and slow effects of chronic nutrient toxicity are a major public health concern. Since food is potentially important for the development of "metabolic memory", there is a need for more information on the type of nutrients causing adverse or toxic effects. We now know that metabolic alterations produced by excessive intake of some nutrients, drugs and chemicals directly impact epigenetic regulation. We envision that understanding how metabolic pathways are coordinated by environmental and genetic factors will provide novel insights for the treatment of metabolic diseases. New methods will enable the assembly and analysis of large sets of complex molecular and clinical data for understanding how inflammation and mitochondria affect bioenergetics, epigenetics and health. Collectively, the observations we highlight indicate that energy utilization and disease are intimately connected by epigenetics. The challenge is to incorporate metabolo-epigenetic data in better interpretations of disease, to expedite therapeutic targeting of key pathways linking nutritional toxicity and metabolism. An additional concern is that changes in the parental phenotype are detectable in the methylome of subsequent offspring. The effect might create a menace to future generations and preconceptional considerations. Copyright © 2016 Elsevier Ltd. All rights reserved.

Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 02786915

Author's mail: jorge.camps@urv.cat jorge.joven@urv.cat

Author identifier: 0000-0002-3165-3640 0000-0003-2749-4541

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/pii/S0278691516302721

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Food And Chemical Toxicology. 96 191-204

APA: Hernández-Aguilera A; Fernández-Arroyo S; Cuyàs E; Luciano-Mateo F; Cabre N; Camps J; Lopez-Miranda J; Menendez J; Joven J (2016). Epigenetics and nutrition-related epidemics of metabolic diseases: Current perspectives and challenges. Food And Chemical Toxicology, 96(), 191-204. DOI: 10.1016/j.fct.2016.08.006

Article's DOI: 10.1016/j.fct.2016.08.006

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications