Author, as appears in the article.: Smith C.E., Coltell O., Sorlí J.V., Estruch R., Martínez-González M.Á., Salas-Salvadó J., Fitó M., Arós F., Dashti H.S., Lai C.Q., Miró L., Serra-Majem L., Gómez-Gracia E., Fiol M., Ros E., Aslibekyan S., Hidalgo B., Neuhouser M.L., Di C., Tucker K.L., Arnett D.K., Ordovás J.M., Corella D.

Department: Bioquímica i Biotecnologia

URV's Author/s: Salas Salvadó, Jorge

Keywords: Mortality Mcm6-rs3754686 Cardiovascular biomarkers

Abstract: Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n???20,089) evaluated associations between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics, African-American and Whites) and Mediterranean populations. Moreover, we analyzed longitudinal associations with milk, CVD and mortality in PREDIMED), a randomized Mediterranean diet (MedDiet) intervention trial (n?=?7185). The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) was strongly associated with higher milk intake, but inconsistently associated with glucose and lipids, and not associated with CVD or total mortality in the whole population. Heterogeneity analyses suggested some sex-specific associations. The T-allele was associated with higher CVD and mortality risk in women but not in men (P-sex interaction:0.005 and 0.032, respectively), mainly in the MedDiet group. However, milk intake was not associated with CVD biomarkers, CVD or mortality either generally or in sub-groups. Although MCM6-rs3754686 is a good milk intake proxy in these populations, attributing its associations with CVD and mortality in Mediterranean women to milk is unwarranted, as other factors limiting the assumption of causality in Mendelian randomization may exist.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20452322

Author's mail: jordi.salas@urv.cat

Author identifier: 0000-0003-2700-7459

Record's date: 2023-04-01

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.nature.com/articles/srep33188

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Scientific Reports. 6 (33188): 33188-

APA: Smith C.E., Coltell O., Sorlí J.V., Estruch R., Martínez-González M.Á., Salas-Salvadó J., Fitó M., Arós F., Dashti H.S., Lai C.Q., Miró L., Serra-Maje (2016). Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. Scientific Reports, 6(33188), 33188-. DOI: 10.1038/srep33188

Article's DOI: 10.1038/srep33188

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications