Author, as appears in the article.: Martinez-Perez, Bruno; Ejarque, Miriam; Gutierrez, Cristina; Nunez-Roa, Catalina; Roche, Kelly; Vila-Bedmar, Rocio; Ballesteros, Monica; Redondo-Angulo, Ibon; Planavila, Anna; Villarroya, Francesc; Vendrell, Joan; Fernandez-Veledo, Sonia; Megia, Ana;

Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques

URV's Author/s: Fernandez Veledo, Sonia / Megía Colet, Ana / Vendrell Ortega, Juan José

Keywords: Obesity Lipid-metabolism Insulin-resistance Gestational diabetes-mellitus Fat Fasting plasma-glucose Cord blood irisin Circulating betatrophin levels Birth-weight Beta-cell proliferation

Abstract: Angiopoietin-like protein 8 (ANGPTL8), a protein implicated in lipid and glucose homeostasis, is present only in mammals, suggesting that it is involved in processes unique to these vertebrates such as pregnancy and homeothermy. We explored the role of ANGPTL8 in maternal-fetal crosstalk and its relationship with newborn adiposity. In a longitudinal analysis of healthy pregnant women, ANGPTL8 levels decreased progressively during pregnancy although remained higher than levels in the postpartum period. In a cross-sectional observational study of women with or without gestational diabetes mellitus (GDM), and their offspring, ANGPTL8 levels were higher in venous cord blood than those in maternal blood and were significantly lower in GDM patients than those in healthy women. Infants small for gestational age and with low-fat mass had the highest ANGPTL8 cord blood levels. Studies in vitro revealed that ANGPTL8 was secreted by brown adipocytes and its expression was increased in experimental models of white-to-brown fat conversion. In addition, ANGPTL8 induced the expression of markers of brown adipocytes. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition.Copyright © 2016 Elsevier Inc. All rights reserved.

Research group: Grup de Recerca Biomèdica HJ23

Thematic Areas: Saúde coletiva Public health, environmental and occupational health Physiology (medical) Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Medical laboratory technology Interdisciplinar General medicine Farmacia Ciências biológicas ii Ciências biológicas i Ciências ambientais Biochemistry (medical)

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19315244

Author's mail: sonia.fernandez@urv.cat juanjose.vendrell@urv.cat ana.megia@urv.cat

Author identifier: 0000-0003-2906-3788 0000-0002-6994-6115 0000-0002-5101-9452

Record's date: 2023-03-05

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.translationalres.com/article/S1931-5244(16)30105-0/fulltext

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Translational Research. 178 1-12

APA: Martinez-Perez, Bruno; Ejarque, Miriam; Gutierrez, Cristina; Nunez-Roa, Catalina; Roche, Kelly; Vila-Bedmar, Rocio; Ballesteros, Monica; Redondo-Angul (2016). Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth. Translational Research, 178(), 1-12. DOI: 10.1016/j.trsl.2016.06.012

Article's DOI: 10.1016/j.trsl.2016.06.012

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications