Author, as appears in the article.: Storniolo C., Casillas R., Bulló M., Castañer O., Ros E., Sáez G., Toledo E., Estruch R., Ruiz-Gutiérrez V., Fitó M., Martínez-González M., Salas-Salvadó J., Mitjavila M., Moreno J.

Department: Bioquímica i Biotecnologia Bioquímica i Biotecnologia

URV's Author/s: Bulló Bonet, Mònica / Salas Salvadó, Jorge

Keywords: Predimed study Oxidative stress Nitric oxide Hypertension Endothelin-1 oxidative stress nitric oxide hypertension endothelin-1

Abstract: Serum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension. Considering that traditional Mediterranean diet (TMD) reduces blood pressure (BP), the aim of this study was to analyze whether TMD induced changes on endothelial physiology elements such as NO, ET-1 and ET-1 receptors which are involved in BP control.Non-smoking women with moderate hypertension were submitted for 1 year to interventions promoting adherence to the TMD, one supplemented with extra virgin olive oil (EVOO) and the other with nuts versus a control low-fat diet (30 participants/group). BP, NO, ET-1 and related gene expression as well as oxidative stress biomarkers were measured.Serum NO and systolic BP (SBP) or diastolic BP (DBP) were negatively associated at baseline, as well as between NO and ET-1. Our findings also showed a DBP reduction with both interventions. A negative correlation was observed between changes in NO metabolites concentration and SBP or DBP after the intervention with TMD + EVOO (p = 0.033 and p = 0.044, respectively). SBP reduction was related to an impairment of serum ET-1 concentrations after the intervention with TMD + nuts (p = 0.008). We also observed changes in eNOS, caveolin 2 and ET-1 receptors gene expression which are related to NO metabolites levels and BP.The changes in NO and ET-1 as well as ET-1 receptors gene expression explain, at least partially, the effect of EVOO or nuts on lowering BP among hypertensive women.

Research group: Alimentació, Nutrició, Creixement i Salut Mental

Thematic Areas: Serviço social Saúde coletiva Química Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14366207

Author's mail: jordi.salas@urv.cat monica.bullo@urv.cat

Author identifier: 0000-0003-2700-7459 0000-0002-0218-7046

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://link.springer.com/article/10.1007/s00394-015-1060-5

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: European Journal Of Nutrition. 56 (1): 89-97

APA: Storniolo C., Casillas R., Bulló M., Castañer O., Ros E., Sáez G., Toledo E., Estruch R., Ruiz-Gutiérrez V., Fitó M., Martínez-González M., Salas-Salv (2017). A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women. European Journal Of Nutrition, 56(1), 89-97. DOI: 10.1007/s00394-015-1060-5

Article's DOI: 10.1007/s00394-015-1060-5

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications