Author, as appears in the article.: Yu, Edward; Ruiz-Canela, Miguel; Guasch-Ferre, Marta; Zheng, Yan; Toledo, Estefania; Clish, Clary B.; Salas-Salvado, Jordi; Liang, Liming; Wang, Dong D.; Corella, Dolores; Fito, Montse; Gomez-Gracia, Enrique; Lapetra, Jose; Estruch, Ramon; Ros, Emilio; Cofan, Montserrat; Aros, Fernando; Romaguera, Dora; Serra-Majem, Lluis; Sorli, Jose V.; Hu, Frank B.; Martinez-Gonzalez, Miguel A.;

Department: Bioquímica i Biotecnologia

URV's Author/s: Salas Salvadó, Jorge

Keywords: Tryptophan Stroke Nutrition Mortality Metabolomics Metabolism Mediterranean diet Kynurenine pathway Interferon-gamma Inflammation Epidemiology Degradation Consumption Cardiovascular disease Atherosclerosis 3-hydroxyanthranilic acid nutrition metabolomics mediterranean diet epidemiology cardiovascular disease

Abstract: Background: During development of cardiovascular disease (CVD), interferon-?-mediated inflammation accelerates degradation of tryptophan into downstream metabolites. A Mediterranean diet (MedDiet) consisting of a high intake of extra-virgin olive oil (EVOO), nuts, fruits, vegetables, and cereals has been demonstrated to lower the risk of CVD. The longitudinal relation between tryptophan and its downstream metabolites and CVD in the context of a MedDiet is unstudied.Objective: We sought to investigate the relation between metabolites in the tryptophan-kynurenine pathway and CVD in the context of a MedDiet pattern.Methods: We used a case-cohort design nested in the Prevención con Dieta Mediterránea randomized controlled trial. There were 231 CVD cases (stroke, myocardial infarction, cardiovascular death) among 985 participants over a median of 4.7 y of follow-up [mean ± SD age: 67.6 ± 6.1 y; 53.7% women; mean ± SD body mass index (in kg/m2): 29.7 ± 3.7]. We assessed plasma tryptophan, kynurenine, kynurenic acid, 3-hydroxyanthranilic acid, and quinolinic acid concentrations at baseline and after 1 y of intervention with a MedDiet. We combined these metabolites in a kynurenine risk score (KRS) by weighting each metabolite by the adjusted coefficient of its associations with CVD. Cox models were used in the primary analysis.Results: Increases in tryptophan after 1 y were associated with a lower risk of composite CVD (HR per SD: 0.79; 95% CI: 0.63, 0.98). The baseline kynurenic acid concentration was associated with a higher risk of myocardial infarction and coronary artery disease death but not stroke. A higher KRS was more strongly associated with CVD in the control group than in the 2 intervention groups (P-interaction = 0.003). Adjustment for changes in plasma tryptophan attenuated the inverse association between MedDiet+EVOO and CVD.Conclusions: An increase in the plasma tryptophan concentration was significantly associated with a decreased risk of CVD. A MedDiet may counteract the deleterious effects of a high kynurenine risk score.© 2017 American Society for Nutrition.

Thematic Areas: Serviço social Saúde coletiva Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00223166

Author's mail: jordi.salas@urv.cat

Author identifier: 0000-0003-2700-7459

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://academic.oup.com/jn/article/147/3/314/4584801

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Nutrition. 147 (3): 314-322

APA: Yu, Edward; Ruiz-Canela, Miguel; Guasch-Ferre, Marta; Zheng, Yan; Toledo, Estefania; Clish, Clary B.; Salas-Salvado, Jordi; Liang, Liming; Wang, Dong (2017). Increases in Plasma Tryptophan Are Inversely Associated with Incident Cardiovascular Disease in the Prevencion con Dieta Mediterranea (PREDIMED) Study. Journal Of Nutrition, 147(3), 314-322. DOI: 10.3945/jn.116.241711

Article's DOI: 10.3945/jn.116.241711

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications