Author, as appears in the article.: Guasch-Ferre, Marta; Becerra-Tomas, Nerea; Ruiz-Canela, Miguel; Corella, Dolores; Schroeder, Helmut; Estruch, Ramon; Ros, Emilio; Aros, Fernando; Gomez-Gracia, Enrique; Fiol, Miquel; Serra-Majem, Lluis; Lapetra, Jose; Basora, Josep; Martin-Calvo, Nerea; Portoles, Olga; Fito, Montserrat; Hu, Frank B.; Forga, Lluis; Salas-Salvado, Jordi;

Department: Bioquímica i Biotecnologia Medicina i Cirurgia

URV's Author/s: Basora Gallisa, Josep / Becerra Tomás, Nerea / Castro Salomó, Antoni / Salas Salvadó, Jorge

Keywords: Womens health W-3 fatty acids Type 2 diabetes Saturated fat Red meat Randomized-trial Predimed study Omega-3 fatty acids Monounsaturated fat Metabolic syndrome Men Insulin-resistance Impaired glucose-tolerance Fat subtypes Dose-response metaanalysis Dietary fat Cohort Cardiovascular-disease ?-3 fatty acids type 2 diabetes saturated fat predimed study monounsaturated fat fat subtypes dietary fat

Abstract: Background: The associations between dietary fat and cardiovascular disease have been evaluated in several studies, but less is known about their influence on the risk of diabetes.Objective: We examined the associations between total fat, subtypes of dietary fat, and food sources rich in saturated fatty acids and the incidence of type 2 diabetes (T2D).Design: A prospective cohort analysis of 3349 individuals who were free of diabetes at baseline but were at high cardiovascular risk from the PREvención con DIeta MEDiterránea (PREDIMED) study was conducted. Detailed dietary information was assessed at baseline and yearly during the follow-up using a food frequency questionnaire. Multivariable Cox proportional hazards models were used to estimate T2D HRs and 95% CIs according to baseline and yearly updated fat intake.Results: We documented 266 incident cases during 4.3 y of follow-up. Baseline saturated and animal fat intake was not associated with the risk of T2D. After multivariable adjustment, participants in the highest quartile of updated intake of saturated and animal fat had a higher risk of diabetes than the lowest quartile (HR: 2.19; 95% CI: 1.28, 3.73; and P-trend = 0.01 compared with HR: 2.00; 95% CI: 1.29, 3.09; and P-trend < 0.01, respectively). In both the Mediterranean diet and control groups, participants in the highest quartile of updated animal fat intake had an ?2-fold higher risk of T2D than their counterparts in the lowest quartile. The consumption of 1 serving of butter and cheese was associated with a higher risk of diabetes, whereas whole-fat yogurt intake was associated with a lower risk.Conclusions: In a Mediterranean trial focused on dietary fat interventions, baseline intake of saturated and animal fat was not associated with T2D incidence, but the yearly updated intake of saturated and animal fat was associated with a higher risk of T2D. Cheese and butter intake was associated with a higher risk of T2D, whereas whole-fat yogurt intake was associated with a lower risk of T2D. This trial was registered at www.isrctn.com as ISRCTN35739639.© 2017 American Society for Nutrition.

Research group: Alimentació, Nutrició, Creixement i Salut Mental

Thematic Areas: Serviço social Saúde coletiva Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Enfermagem Educação física Ciências biológicas ii Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00029165

Author's mail: josep.basora@urv.cat nerea.becerra@urv.cat jordi.salas@urv.cat antoni.castro@urv.cat josep.basora@urv.cat

Author identifier: 0000-0002-4429-6507 0000-0003-2700-7459 0000-0001-5441-6333

Record's date: 2023-09-02

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://academic.oup.com/ajcn/article/105/3/723/4569701

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: American Journal Of Clinical Nutrition. 105 (3): 723-735

APA: Guasch-Ferre, Marta; Becerra-Tomas, Nerea; Ruiz-Canela, Miguel; Corella, Dolores; Schroeder, Helmut; Estruch, Ramon; Ros, Emilio; Aros, Fernando; Gome (2017). Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevencion con Dieta Mediterranea (PREDIMED) study. American Journal Of Clinical Nutrition, 105(3), 723-735. DOI: 10.3945/ajcn.116.142034

Article's DOI: 10.3945/ajcn.116.142034

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications