Author, as appears in the article.: Arpón A., Riezu-Boj J., Milagro F., Marti A., Razquin C., Martínez-González M., Corella D., Estruch R., Casas R., Fitó M., Ros E., Salas-Salvadó J., Martínez J.

Department: Bioquímica i Biotecnologia

URV's Author/s: Salas Salvadó, Jorge

Keywords: Methylation Mediterranean Epigenetics Dna Diet Adherence mediterranean epigenetics dna diet adherence

Abstract: Epigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events. Meanwhile, Mediterranean diet (MedDiet) has demonstrated favourable effects on cardiovascular risk, blood pressure, inflammation and other complications related to excessive adiposity. Some of these effects could be mediated by epigenetic modifications. Therefore, the objective of this study was to investigate whether the adherence to MedDiet is associated with changes in the methylation status from peripheral blood cells. A subset of 36 individuals was selected within the Prevención con Dieta Mediterránea (PREDIMED)-Navarra study, a randomised, controlled, parallel trial with three groups of intervention in high cardiovascular risk volunteers, two with a MedDiet and one low-fat control group. Changes in methylation between baseline and 5 years were studied. DNA methylation arrays were analysed by several robust statistical tests and functional classifications. Eight genes related to inflammation and immunocompetence (EEF2, COL18A1, IL4I1, LEPR, PLAGL1, IFRD1, MAPKAPK2, PPARGC1B) were finally selected as changes in their methylation levels correlated with adherence to MedDiet and because they presented sensitivity related to a high variability in methylation changes. Additionally, EEF2 methylation levels positively correlated with concentrations of TNF-? and CRP. This report is apparently the first showing that adherence to MedDiet is associated with the methylation of the reported genes related to inflammation with a potential regulatory impact.

Thematic Areas: Physiology Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biochemistry & molecular biology Biochemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 11387548

Author's mail: jordi.salas@urv.cat

Author identifier: 0000-0003-2700-7459

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://link.springer.com/article/10.1007/s13105-017-0552-6

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Physiology And Biochemistry. 73 (3): 1-11

APA: Arpón A., Riezu-Boj J., Milagro F., Marti A., Razquin C., Martínez-González M., Corella D., Estruch R., Casas R., Fitó M., Ros E., Salas-Salvadó J., M (2016). Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells. Journal Of Physiology And Biochemistry, 73(3), 1-11. DOI: 10.1007/s13105-017-0552-6

Article's DOI: 10.1007/s13105-017-0552-6

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications