Author, as appears in the article.: Bargallo, Nuria; Gilabert, Rosa; Romero-Mamani, Edwin-Saul; Cofan, Montserrat; Calder, Philip C.; Fito, Montserrat; Corella, Dolores; Salas-Salvado, Jordi; Ruiz-Canela, Miguel; Estruch, Ramon; Ros, Emilio; Sala-Vila, Aleix;

Department: Bioquímica i Biotecnologia

URV's Author/s: Salas Salvadó, Jorge

Keywords: Variability Spain Population Omega-3 index Omega-3 Myocardial-infarction Imaging Fish Fatty-acids Disease Diet Cholesterol Atherosclerosis American-heart-association imaging fish diet atherosclerosis

Abstract: Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ?2.0 mm (n = 79). The latter were asked to undergo contrast-enhanced 3T magnetic resonance imaging (MRI) and were subsequently grouped into absence (n = 31) or presence (n = 27) of MRI-detectable plaque lipid, a main feature of unstable atheroma plaques. We determined the red blood cell (RBC) proportion of EPA (a valid marker of long-term EPA intake) at enrolment by gas chromatography. In multivariate models, EPA related inversely to MRI-assessed plaque lipid volume, but not to maximum intima-media thickness of internal carotid artery, plaque burden, or MRI-assessed normalized wall index. The inverse association between EPA and plaque lipid content in patients with advanced atherosclerosis supports the notion that this fatty acid might improve cardiovascular health through stabilization of advanced atheroma plaques.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20726643

Author's mail: jordi.salas@urv.cat

Author identifier: 0000-0003-2700-7459

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/9/9/1036

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 9 (9): E1036-

APA: Bargallo, Nuria; Gilabert, Rosa; Romero-Mamani, Edwin-Saul; Cofan, Montserrat; Calder, Philip C.; Fito, Montserrat; Corella, Dolores; Salas-Salvado, J (2017). Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk. Nutrients, 9(9), E1036-. DOI: 10.3390/nu9091036

Article's DOI: 10.3390/nu9091036

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications