Author, as appears in the article.: Razquin C; Liang L; Toledo E; Clish C; Ruiz-Canela M; Zheng Y; Wang D; Corella D; Castaner O; Ros E; Aros F; Gomez-Gracia E; Fiol M; Santos-Lozano J; Guasch-Ferre M; Serra-Majem L; Sala-Vila A; Buil-Cosiales P; Bullo M; Fito M; Portoles O; Estruch R; Salas-Salvado J; Hu F; Martinez-Gonzalez M

Department: Bioquímica i Biotecnologia

URV's Author/s: Salas Salvadó, Jorge

Keywords: Primary prevention Mediterranean diet Lipidomics Case-cohort Cardiovascular disease mediterranean diet lipidomics case-cohort cardiovascular disease

Abstract: The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. In the frame of the PREDIMED trial, our aim was to examine the associations of baseline lipidome patterns or their changes with the risk of clinical CVD events.We included 983 participants in our case-cohort study. The end-point was the incidence of major CVD during 4.8years of median follow-up. We repeatedly measured 202 plasma known lipid metabolites at baseline and after 1-year of intervention. Principal component analysis was used to identify lipidome factors. Among the 15 identified factors, 7 were significantly associated with CVD. Considering common patterns among factors, lipids were grouped (summed) into scores.After adjustment for traditional CVD risk factors, scores of baseline polyunsaturated phosphatidylcholines (PC)/lysoPC/PC-plasmalogens and polyunsaturated cholesterol esters (CE) showed inverse associations with CVD (p=0.036 and 0.012, respectively); whereas scores of monoacylglycerols (MAGs)/diacylglycerols (DAGs) and short triacylglycerols (TAGs) showed a direct association with CVD (p=0.026 and 0.037, respectively). Baseline phosphatidylethanolamines (PEs) and their 1-y changes tended to be associated with higher CVD risk (p=0.066 and 0.081, respectively). We did not find a significant effect of the intervention with the Mediterranean Diet on these scores.Our study suggests that polyunsaturated PCs and CEs may confer protection against CVD. In contrast, MAGs, DAGs, TAGs and PEs appeared to be associated with higher CVD risk.Copyright © 2017 Elsevier B.V. All rights reserved.

Thematic Areas: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Biodiversidade Antropologia / arqueologia

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 01675273

Author's mail: jordi.salas@urv.cat

Author identifier: 0000-0003-2700-7459

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.internationaljournalofcardiology.com/article/S0167-5273(17)34079-2/fulltext#%20

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: International Journal Of Cardiology. 253 (): 126-132

APA: Razquin C; Liang L; Toledo E; Clish C; Ruiz-Canela M; Zheng Y; Wang D; Corella D; Castaner O; Ros E; Aros F; Gomez-Gracia E; Fiol M; Santos-Lozano J; (2018). Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial: A case-cohort study. International Journal Of Cardiology, 253(), 126-132. DOI: 10.1016/j.ijcard.2017.10.026

Article's DOI: 10.1016/j.ijcard.2017.10.026

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications