Author, as appears in the article.: Ruiz-Canela M; Guasch-Ferré M; Toledo E; Clish C; Razquin C; Liang L; Wang D; Corella D; Estruch R; Hernáez Á; Yu E; Gómez-Gracia E; Zheng Y; Arós F; Romaguera D; Dennis C; Ros E; Lapetra J; Serra-Majem L; Papandreou C; Portoles O; Fitó M; Salas-Salvadó J; Hu F; Martínez-González M

Department: Bioquímica i Biotecnologia

URV's Author/s: Salas Salvadó, Jorge

Keywords: Type 2 diabetes Mediterranean diet Branched-chain amino acids Aromatic amino acids mediterranean diet branched-chain amino acids aromatic amino acids

Abstract: Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial.We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvención con DIeta MEDiterránea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n?=?273), a MedDiet+nuts (n?=?324) or a control diet (n?=?295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial.Elevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend?=?0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend<0.001). Increases in BCAA score at 1 year were associated with higher type 2 diabetes risk in the control group with HR per SD?=?1.61 (95% CI 1.02, 2.54), but not in the MedDiet groups (p for interaction <0.001). The MedDiet+extra-virgin olive oil significantly reduced BCAA levels after 1 year of intervention (p?= 0.005 vs the control group).Our results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence. Clinical trial number: SRCTN35739639 ( www.controlled-trials.com ).

Thematic Areas: Saúde coletiva Química Medicina veterinaria Medicina i Internal medicine Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14320428

Author's mail: jordi.salas@urv.cat

Author identifier: 0000-0003-2700-7459

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://link.springer.com/article/10.1007%2Fs00125-018-4611-5

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Diabetologia. 61 (7): 1560-1571

APA: Ruiz-Canela M; Guasch-Ferré M; Toledo E; Clish C; Razquin C; Liang L; Wang D; Corella D; Estruch R; Hernáez Á; Yu E; Gómez-Gracia E; Zheng Y; Arós F; (2018). Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial. Diabetologia, 61(7), 1560-1571. DOI: 10.1007/s00125-018-4611-5

Article's DOI: 10.1007/s00125-018-4611-5

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications