Author, as appears in the article.: Auguet, Teresa; Aragones, Gemma; Berlanga, Alba; Martinez, Salome; Sabench, Fatima; Binetti, Jessica; Aguilar, Carmen; Porras, Jose Antonio; Molina, Alicia; Del Castillo, Daniel; Richart, Cristobal;

Department: Medicina i Cirurgia

URV's Author/s: Aguilar Crespillo, Carmen Isabel / ARAGONÈS BARGALLÓ, GEMMA / Auguet Quintillà, Maria Teresa / BERLANGA BUSTOS, ALBA / Binetti, Jessica Angela / Del Castillo Déjardin, Daniel / Martínez González, María Salomé / MOLINA LÓPEZ, ALICIA / Porras Ledantes, Jose Antonio / Richart Jurado, Cristobal Manuel / Sabench Pereferrer, Fàtima

Keywords: Hashtag Etiqueta «#» @uroweb @residentesaeu @infoAeu

Abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries. Both iron and lipid metabolism seem to be involved in its pathogenesis. We aimed to assess the relationship between levels of hepcidin, the master iron-regulatory protein, in plasma and the presence of NAFLD in morbidly obese (MO) patients, and to investigate the association between the hepatic expression of the main iron and lipid metabolism -related genes.Enzyme-linked immunosorbent assay was used to measure plasma hepcidin levels in 49 normal-weight control women, 23 MO women with normal liver (NL) histology and 46 MO women with NAFLD. The mRNA expression of hepcidin, the main iron metabolism-related genes, and the main lipid-metabolism genes was quantified by qRT-PCR in liver biopsies from members of the MO group undergoing bariatric surgery.Circulating hepcidin levels were significantly greater in MO than in normal-weight control women. However, there were no significant differences between MO women with NL and those with NAFLD. PCR analysis showed increased expression of hepcidin, FPN1, TfR1 and TfR2 in the liver of MO NAFLD women compared to those with NL. Moreover, a positive association of hepatic hepcidin mRNA expression and the iron metabolism-related genes was found with some key genes involved in the lipid metabolism.These findings suggest that circulating hepcidin levels are associated with obesity but not with the presence of NAFLD. However, the hepatic expression of hepcidin and the iron metabolism-related genes seem to play a role in regulating lipid metabolism pathways in liver, which has implications for NAFLD pathogenesis.

Thematic Areas: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19326203

Author's mail: joseantonio.porras@urv.cat mariasalome.martinez@urv.cat cristobalmanuel.richart@urv.cat danieldel.castillo@urv.cat mariateresa.auguet@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat fatima.sabench@urv.cat jessicaangela.binetti@estudiants.urv.cat

Author identifier: 0000-0001-6418-1822 0000-0001-6185-2889 0000-0003-0852-6739 0000-0003-0456-3102 0000-0001-7024-7824 0000-0003-0396-6428 0000-0002-4440-562X 0000-0002-4440-562X 0000-0002-9262-8756 0000-0001-9660-7752

Record's date: 2023-03-11

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187065

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Plos One. 12 (10): e0187065-

APA: Auguet, Teresa; Aragones, Gemma; Berlanga, Alba; Martinez, Salome; Sabench, Fatima; Binetti, Jessica; Aguilar, Carmen; Porras, Jose Antonio; Molina, A (2017). Hepcidin in morbidly obese women with nonalcoholic fatty liver disease. Plos One, 12(10), e0187065-. DOI: 10.1371/journal.pone.0187065

Article's DOI: 10.1371/journal.pone.0187065

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications