Author, as appears in the article.: Escribano J, Luque V, Canals-Sans J, Ferré N, Koletzko B, Grote V, Weber M, Gruszfeld D, Szott K, Verduci E, Riva E, Brasselle G, Poncelet P, Closa-Monasterolo R, EU Childhood Obesity Project Group.

Department: Psicologia Medicina i Cirurgia

URV's Author/s: Canals Sans, Josefa / Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Luque Moreno, Verònica

Keywords: Protein Neurodevelopment Metabolic programming Mental performance Infants metabolic programming mental performance infants

Abstract: In humans, maximum brain development occurs between the third trimester of gestation and 2 years of life. Nutrition during these critical windows of rapid brain development might be essential for later cognitive functioning and behaviour. In the last few years, trends on protein recommendations during infancy and childhood have tended to be lower than that in the past. It remains to be demonstrated that lower protein intakes among healthy infants, a part of being able to reduce obesity risk, is safe in terms of mental performance achievement. Secondary analyses of the EU CHOP, a clinical trial in which infants from five European countries were randomised to be fed a higher or a lower protein content formula during the 1st year of life. Children were assessed at the age of 8 years with a neuropsychological battery of tests that included assessments of memory (visual and verbal), attention (visual, selective, focused and sustained), visual-perceptual integration, processing speed, visual-motor coordination, verbal fluency and comprehension, impulsivity/inhibition, flexibility/shifting, working memory, reasoning, visual-spatial skills and decision making. Internalising, externalising and total behaviour problems were assessed using the Child Behaviour Checklist 4¿18. Adjusted analyses considering factors that could influence neurodevelopment, such as parental education level, maternal smoking, child¿s gestational age at birth and head circumference, showed no differences between feeding groups in any of the assessed neuropsychological domains and behaviour. In summary, herewith we report on the safety of lower protein content in infant formulae (closer to the content of human milk) according to long-term mental performance.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14752662

Author's mail: veronica.luque@urv.cat joaquin.escribano@urv.cat josefa.canals@urv.cat natalia.ferre@urv.cat ricardo.closa@urv.cat

Author identifier: 0000-0003-2615-8175 0000-0002-5041-459X 0000-0002-6209-9558 0000-0002-2838-1525 0000-0002-9963-4163

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/mental-performance-in-8yearold-children-fed-reduced-protein-content-formula-during-the-1st-year-of-life-safety-analysis-of-a-randomised-clinical-trial/9F19A509EF7BABC0B11D276ED51EBDB1#

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: British Journal Of Nutrition. 122 (s1): S22-S30

APA: Escribano J, Luque V, Canals-Sans J, Ferré N, Koletzko B, Grote V, Weber M, Gruszfeld D, Szott K, Verduci E, Riva E, Brasselle G, Poncelet P, Closa-Mo (2019). Mental performance in 8-year-old children fed reduced protein content formula during the 1st year of life: safety analysis of a randomized clinical trial. British Journal Of Nutrition, 122(s1), S22-S30. DOI: 10.1017/S0007114515000768

Article's DOI: 10.1017/s0007114515000768

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

Publication Type: Journal Publications