Author, as appears in the article.: Catalán Ú., López de las Hazas M., Piñol C., Rubió L., Motilva M., Fernandez-Castillejo S., Solà R.

Department: Medicina i Cirurgia

URV's Author/s: Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / Solà Alberich, Rosa Maria

Keywords: Hydroxytyrosol metabolites Hydroxytyrosol Human aortic endothelial cells Atherosclerosis Apoe mice ?/?

Abstract: The main aim of this work is to gain insight into the potential mechanisms of hydroxytyrosol (HT) and its main plasmatic metabolites (HTmet) that improve the endothelial function. Feeding ApoE−/− mice with 10 mg/kg/ day of HT derivatives for 12 weeks significantly reduced E-selectin, VCAM-1, MCP-1, ICAM-1, and F4/80 expression compared with the control group in the isolated aorta. Further in-vitro mechanistic assays revealed that both HT and HTmet could reduce the adhesion of Jurkat-T-lymphocytes to human aortic endothelial cells at 1-5 μM, significantly greater reductions being observed with HTmet. This process appeared to be regulated by the MAPK pathway through the inactivation of p38δ, JNK1-3, CREB, AKT3, p53 and P70 S6 Kinase. We concluded that supplementation with HT precursors from olive oil might attenuate the initial steps of atherosclerosis at a molecular level. The reduction of lymphocyte adhesion and the modulation of MAPK pathway by HTmet could explain this phenomenon.

Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 17564646

Author's mail: ursula.catalan@urv.cat rosa.sola@urv.cat

Author identifier: 0000-0001-8884-9823 0000-0002-8359-235X

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S1756464617306795?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Functional Foods. 40 280-291

APA: Catalán Ú., López de las Hazas M., Piñol C., Rubió L., Motilva M., Fernandez-Castillejo S., Solà R. (2018). Hydroxytyrosol and its main plasma circulating metabolites attenuate the initial steps of atherosclerosis through inhibition of the MAPK pathway. Journal Of Functional Foods, 40(), 280-291. DOI: 10.1016/j.jff.2017.11.007

Article's DOI: 10.1016/j.jff.2017.11.007

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications