Author, as appears in the article.: Magre M, Pàmies O, Diéguez M

Department: Química Física i Inorgànica

URV's Author/s: Diéguez Fernández, Montserrat

Keywords: Phosphite-oxazoline ligands Iridium Hydrogenation Asymmetric catalysis ?-enamides

Abstract: Simple Ir-PHOX-based phosphite-oxazoline catalysts have been successfully applied in the asymmetric hydrogenation of cyclic ¿-enamides providing better enantioselectivities than previous effective Ru and Rh catalysts. This protocol allows the synthesis of 2-aminotetralines and 3-aminochromanes, key structural units found in many therapeutic agents and biologically active natural products, in high chemical yields and enantioselectivities (ee's up to 99%). High enantioselectivities have also been achieved in the hydrogenation of cyclic β-enamides.

Thematic Areas: Química Materiais Interdisciplinar General chemistry Engenharias ii Ciências agrárias i Chemistry, physical Chemistry (miscellaneous) Chemistry (all) Catalysis Astronomia / física

ISSN: 21555435

Author's mail: montserrat.dieguez@urv.cat

Author identifier: 0000-0002-8450-0656

Record's date: 2023-02-18

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Acs Catalysis. 6 (8): 5186-5190

APA: Magre M, Pàmies O, Diéguez M (2016). PHOX-Based Phosphite-Oxazoline Ligands for the Enantioselective Ir-Catalyzed Hydrogenation of Cyclic β-Enamides. Acs Catalysis, 6(8), 5186-5190. DOI: 10.1021/acscatal.6b01314

Article's DOI: 10.1021/acscatal.6b01314

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications