Author, as appears in the article.: Lanuza M; Tomàs J; Garcia N; Cilleros-Mañé V; Just-Borràs L; Tomás M

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / Just Borràs, Laia / Tomas Marginet, Marta

Keywords: Hashtag Etiqueta «#» @uroweb @residentesaeu @infoAeu

Abstract: © 2018 Elsevier Ltd Early in development, each muscle fiber is innervated by multiple neurons. Different activities between nerve terminals on the same junction cause the elimination of all but one of them through Hebbian competition. The molecular basis of this developmental synapse modulation is still being investigated because it is a model for how the nervous system achieves the proper synaptic connectivity and function. The study of the vertebrate neuromuscular junction has proven useful to understand the carefully regulated process of axon withdrawal, locally regulated in the synaptic site by the nerve terminals themselves, the postsynaptic muscle cell and the Schwann cells. In this review, we summarize the multiple factors that have been implicated in axonal competition and synapse elimination.

Thematic Areas: Physiology (medical) Physiology

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 24688673

Author's mail: victor.cilleros@urv.cat marta.tomas@urv.cat laia.just@urv.cat victor.cilleros@urv.cat

Author identifier: 0000-0001-5690-9932 0000-0002-4151-1697 0000-0003-0473-3730 0000-0001-5690-9932

Record's date: 2023-09-02

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/pii/S2468867318300543?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Curr Opin Physiol. 4 25-31

APA: Lanuza M; Tomàs J; Garcia N; Cilleros-Mañé V; Just-Borràs L; Tomás M (2018). Axonal competition and synapse elimination during neuromuscular junction development. Curr Opin Physiol, 4(), 25-31. DOI: 10.1016/j.cophys.2018.04.001

Article's DOI: 10.1016/j.cophys.2018.04.001

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications