Author, as appears in the article.: Clèries R., Ameijide A., Buxó M., Vilardell M., Martínez J.M., Marcos-Gragera R., Vilardell M.L., Carulla M., Espinàs J.A., Galceran J., Borràs J.M., Izquierdo Á.

Department: Medicina i Cirurgia

URV's Author/s: Espinas Pinol, Josep Alfons / Galceran Padrós, Jaume Josep Maria

Keywords: “cure” fraction Women Survival Supervivencia condicional Supervivencia Registries Recurrence Prognosis Probabilities Population Long-term survival Excess mortality Exceso de mortalidad Diagnosis Death Cure fraction Cure Curación Conditional survival Cáncer de mama Breast cancer survival supervivencia condicional supervivencia excess mortality exceso de mortalidad curación conditional survival cáncer de mama breast cancer

Abstract: © 2018 SESPAS Objective: To analyze the population-based survival of breast cancer (CM) diagnosed in early stages estimating the time trends of excess mortality (EM) in the long term in annual and five-year time intervals, and to determine, if possible, a proportion of patients who can be considered cured. Method: We included women diagnosed with BC under the age of 60 years in stages I and II in Girona and Tarragona (N = 2453). The observed (OS) and relative survival (RS) were calculated up to 20 years of follow-up. RS was also estimated at annual (RSI) and in five-year intervals (RS5) to graphically assess the EM. The results are presented by age groups (≤49 and 50-59), stage (I/II) and diagnostic period (1985-1994 and 1995-2004). Results: In stage I, OS and RS were higher during 1995-2004 compared to 1985-1994: 3.5% at 15 years of follow-up and 4.5% at 20-years of follow-up. In 1995-2004, the OS surpassed 80% in stage I patients whereas in stage II it remained below 70%. During 1995-2004, the long-term EM did not level off towards 0 (RSI <1) independently of age group, stage and period of diagnosis. After 15 years of follow-up, the 5-year EM oscillated between 1 and 5% in stage I (RS5 ≥0.95) and between 5 and 10% in stage II. Conclusions: In our cohort, after 15 years of follow-up, it was detected that the annual EM did not disappear and the five-year EM remained between 1 and 10%. Therefore, it was not possible to determine a cure rate of BC during the study period.

Thematic Areas: Sociologia i política Saúde coletiva Public, environmental & occupational health Public health, environmental and occupational health Psicología Odontología Nutrição Interdisciplinar Health policy & services Health care sciences & services General medicine Farmacia Engenharias iv Enfermagem Educação física Economia Ciencias sociales Ciências biológicas i Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 02139111

Author's mail: jaumejosepmaria.galceran@urv.cat

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.sciencedirect.com/science/article/pii/S0213911118302449?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Gaceta Sanitaria. 34 (4): 356-362

APA: Clèries R., Ameijide A., Buxó M., Vilardell M., Martínez J.M., Marcos-Gragera R., Vilardell M.L., Carulla M., Espinàs J.A., Galceran J., Borràs J.M., (2020). Excess mortality among breast cancer patients in early stages in Tarragona and Gerona (Spain) [Exceso de mortalidad en las pacientes con cáncer de mama en estadios precoces en Tarragona y Gerona (España)]. Gaceta Sanitaria, 34(4), 356-362. DOI: 10.1016/j.gaceta.2018.09.008

Article's DOI: 10.1016/j.gaceta.2018.09.008

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications