Author, as appears in the article.: Papandreou C; Li J; Liang L; Bulló M; Zheng Y; Ruiz-Canela M; Yu E; Guasch-Ferré M; Razquin C; Clish C; Corella D; Estruch R; Ros E; Fitó M; Arós F; Serra-Majem L; Rosique N; Martínez-González MA; Hu FB; Salas-Salvadó J

Department: Bioquímica i Biotecnologia Bioquímica i Biotecnologia

URV's Author/s: Bulló Bonet, Mònica / Salas Salvadó, Jorge

Keywords: Hashtag Etiqueta «#» @uroweb @residentesaeu @infoAeu

Abstract: © 2019, The Author(s). Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física

ISSN: 20452322

Author's mail: jordi.salas@urv.cat monica.bullo@urv.cat

Author identifier: 0000-0003-2700-7459 0000-0002-0218-7046

Record's date: 2023-02-18

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Scientific Reports. 9 (1): 2892-

APA: Papandreou C; Li J; Liang L; Bulló M; Zheng Y; Ruiz-Canela M; Yu E; Guasch-Ferré M; Razquin C; Clish C; Corella D; Estruch R; Ros E; Fitó M; Arós F; S (2019). Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism. Scientific Reports, 9(1), 2892-. DOI: 10.1038/s41598-019-39441-6

Article's DOI: 10.1038/s41598-019-39441-6

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

Publication Type: Journal Publications