Author, as appears in the article.: Tomas-Hernandez S, Garcia-Vallvé S, Pujadas G, Valls C, Ojeda-Montes M, Gimeno A, Cereto-Massagué A, Roca-Martinez J, Suárez M, Arola L, Blanco J, Mulero M, Beltran-Debón R

Department: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia

URV's Author/s: Arola Ferrer, Luis Maria / Beltrán Debón, Raúl Alejandro / Blanco Pérez, Jordi / Cereto Massagué, Adrián José / Garcia Vallve, Santiago / Mulero Abellán, Miguel / Pujadas Anguiano, Gerard / Suárez Recio, Manuel / TOMAS HERNÁNDEZ, SARA / Valls Bautista, Cristina

Keywords: O-orsellinaldehyde Nf-κβ Nf-?? Inflammation Ikk-2 Grifola frondosa Apoptosis nf-?? inflammation ikk-2 grifola frondosa apoptosis

Abstract: Metabolic syndrome is a cluster of medical conditions that increases the risk of developing cardiovascular disease and type 2 diabetes. Numerous studies have shown that inflammation is directly involved in the onset of metabolic syndrome and related pathologies. In this study, in silico techniques were applied to a natural products database containing molecules isolated from mushrooms from the Catalan forests to predict molecules that can act as human nuclear-factor κβ kinase 2 (IKK-2) inhibitors. IKK-2 is the main component responsible for activating the nuclear-factor κβ transcription factor (NF-κβ). One of these predicted molecules was o-orsellinaldehyde, a molecule present in the mushroom Grifola frondosa. This study shows that o-orsellinaldehyde presents anti-inflammatory and pro-apoptotic properties by acting as IKK-2 inhibitor. Additionally, we suggest that the anti-inflammatory and pro-apoptotic properties of Grifola frondosa mushroom could partially be explained by the presence of o-orsellinaldehyde on its composition.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Planejamento urbano e regional / demografia Odontología Nutrição Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar General medicine General chemistry General agricultural and biological sciences Food science & technology Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, applied Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Astronomia / física Agriculture, multidisciplinary Agriculture Agricultural and biological sciences (miscellaneous) Agricultural and biological sciences (all)

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00218561

Author's mail: cristina.valls@urv.cat jordi.blanco@urv.cat adrianjose.cereto@urv.cat raul.beltran@urv.cat lluis.arola@urv.cat gerard.pujadas@urv.cat santi.garcia-vallve@urv.cat miquel.mulero@urv.cat manuel.suarez@urv.cat adrianjose.cereto@urv.cat

Author identifier: 0000-0001-5583-5695 0000-0001-8016-0984 0000-0001-9691-1906 0000-0003-2767-1974 0000-0003-2598-8089 0000-0002-0348-7497 0000-0003-0122-8253

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://pubs.acs.org/doi/10.1021/acs.jafc.8b00782

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Agricultural And Food Chemistry. 66 (42): 10952-10963

APA: Tomas-Hernandez S, Garcia-Vallvé S, Pujadas G, Valls C, Ojeda-Montes M, Gimeno A, Cereto-Massagué A, Roca-Martinez J, Suárez M, Arola L, Blanco J, Mul (2018). Anti-inflammatory and Proapoptotic Properties of the Natural Compound o-Orsellinaldehyde. Journal Of Agricultural And Food Chemistry, 66(42), 10952-10963. DOI: 10.1021/acs.jafc.8b00782

Article's DOI: 10.1021/acs.jafc.8b00782

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications