Author, as appears in the article.: Guevara-Suarez, Marcela; Sutton, Deanna A; Cano-Lira, Jose F; Garcia, Dania; Martin-Vicente, Adela; Wiederhold, Nathan; Guarro, Josep; Gene, Josepa

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Cano Lira, José Francisco / García Sánchez, Dania / Gené Díaz, Josepa / Guarro Artigas, Josep

Keywords: Penicillium Molecular phylogeny Fungal identification

Abstract: Penicillium species are some of the most common fungi observed worldwide and have an important economic impact as well as being occasional agents of human and animal mycoses. A total of 118 isolates thought to belong to the genus Penicillium based on morphological features were obtained from the Fungus Testing Laboratory at the University of Texas Health Science Center in San Antonio (United States). The isolates were studied phenotypically using standard growth conditions. Molecular identification was made using two genetic markers, the internal transcribed spacer (ITS) and a fragment of the β-tubulin gene. In order to assess phylogenetic relationships, maximum likelihood and Bayesian inference assessments were used. Antifungal susceptibility testing was performed according to CLSI document M38-A2 for nine antifungal drugs. The isolates were identified within three genera, i.e., Penicillium, Talaromyces, and Rasamsonia The most frequent species in our study were Penicillium rubens, P. citrinum, and Talaromyces amestolkiae The potent in vitro activity of amphotericin B (AMB) and terbinafine (TRB) and of the echinocandins against Penicillium and Talaromyces species might offer a good therapeutic alternative for the treatment of infections caused by these fungi.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Microbiology (medical) Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Ensino Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Ciência da computação Biotecnología Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00951137

Author's mail: josep.guarro@urv.cat jose.cano@urv.cat josepa.gene@urv.cat dania.garcias@urv.cat

Author identifier: 0000-0002-7839-7568 0000-0003-4495-4394 0000-0001-6195-9299 0000-0003-2397-1646

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://jcm.asm.org/content/54/8/2155

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Clinical Microbiology. 54 (8): 2155-2161

APA: Guevara-Suarez, Marcela; Sutton, Deanna A; Cano-Lira, Jose F; Garcia, Dania; Martin-Vicente, Adela; Wiederhold, Nathan; Guarro, Josep; Gene, Josepa (2016). Identification and Antifungal Susceptibility of Penicillium-Like Fungi from Clinical Samples in the United States. Journal Of Clinical Microbiology, 54(8), 2155-2161. DOI: 10.1128/JCM.00960-16

Article's DOI: 10.1128/JCM.00960-16

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications