Author, as appears in the article.: Mario D; Guarro J; Santurio J; Alves S; Capilla J

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep

Abstract: We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.

Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00664804

Author's mail: josep.guarro@urv.cat javier.capilla@urv.cat

Author identifier: 0000-0002-7839-7568 0000-0002-0765-6403

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://aac.asm.org/content/59/8/5018

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Antimicrobial Agents And Chemotherapy. 59 (8): 5018-5021

APA: Mario D; Guarro J; Santurio J; Alves S; Capilla J (2015). In vitro and in vivo efficacy of amphotericin B combined with posaconazole against experimental disseminated sporotrichosis. Antimicrobial Agents And Chemotherapy, 59(8), 5018-5021. DOI: 10.1128/AAC.00052-15

Article's DOI: 10.1128/AAC.00052-15

Entity: Universitat Rovira i Virgili

Journal publication year: 2015

Publication Type: Journal Publications