Author, as appears in the article.: Méndez L., Ciordia S., Fernández M., Juárez S., Ramos A., Pazos M., Gallardo J., Torres J., Nogués M., Medina I.

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Nogués Llort, Maria Rosa

Keywords: Wistar kyoto rat Liver protein regulation High-fat, high-sucrose diet Grape polyphenols Fish oils Bioactive compounds liver protein regulation high-fat, high-sucrose diet grape polyphenols fish oils bioactive compounds

Abstract: This study considered the physiological modulation of liver proteins due to the supplementation with fish oils under two dietary backgrounds: standard or high in fat and sucrose (HFHS), and their combination with grape polyphenols. By using a quantitative proteomics approach, we showed that the capacity of the supplements for regulating proteins depended on the diet; namely, 10 different proteins changed into standard diets, while 45 changed into the HFHS diets and only scarcely proteins were found altered in common. However, in both contexts, fish oils were the main regulatory force, although the addition of polyphenols was able to modulate some fish oils' effects. Moreover, we demonstrated the ability of fish oils and their combination with grape polyphenols in improving biochemical parameters and reducing lipogenesis and glycolysis enzymes, enhancing fatty acid beta-oxidation and insulin signaling and ameliorating endoplasmic reticulum stress and protein oxidation when they are included in an unhealthy diet.

Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Molecular biology Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Endocrinology, diabetes and metabolism Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology Biochemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 09552863

Author's mail: mariarosa.nogues@urv.cat

Author identifier: 0000-0003-4626-5672

Last page: 97

Record's date: 2023-02-18

Journal volume: 41

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0955286316302674?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Nutritional Biochemistry. 41 84-97

APA: Méndez L., Ciordia S., Fernández M., Juárez S., Ramos A., Pazos M., Gallardo J., Torres J., Nogués M., Medina I. (2017). Changes in liver proteins of rats fed standard and high-fat and sucrose diets induced by fish omega-3 PUFAs and their combination with grape polyphenols according to quantitative proteomics. Journal Of Nutritional Biochemistry, 41(), 84-97. DOI: 10.1016/j.jnutbio.2016.12.005

Article's DOI: 10.1016/j.jnutbio.2016.12.005

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

First page: 84

Publication Type: Journal Publications