Articles producció científica> Enginyeria Química

A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats

  • Identification data

    Identifier: imarina:5130730
    Handle: http://hdl.handle.net/20.500.11797/imarina5130730
  • Authors:

    Gil-Cardoso K, Ginés I, Pinent M, Ardévol A, Terra X, Blay M.
  • Others:

    Author, as appears in the article.: Gil-Cardoso K, Ginés I, Pinent M, Ardévol A, Terra X, Blay M.
    Department: Enginyeria Química Bioquímica i Biotecnologia
    URV's Author/s: Ardèvol Grau, Anna / Blay Olivé, Maria Teresa / GINÉS MIR, IRIS / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
    Keywords: Proanthocyanidins Oxidative stress Obesity Intestine Inflammation Gut microbiota Gut Cafeteria diet obesity inflammation gut cafeteria diet zo zonula occludens tj tight junctions rv reverse ros reactive oxygen species pc principal components ocln occludin mpo myeloperoxidase lepr leptin receptor inos isoform of nitric oxide synthase homa-ir homeostasis model assessment of insulin resistance go genetic obesity gi gastrointestinal fw forward caf diet cafeteria diet
    Abstract: The gastrointestinal alterations associated with the consumption of an obesogenic diet, such as inflammation, permeability impairment and oxidative stress, have been poorly explored in both diet-induced obesity (DIO) and genetic obesity. The aim of the present study was to examine the impact of an obesogenic diet on the gut health status of DIO rats in comparison with the Zucker (fa/fa) rat leptin receptor-deficient model of genetic obesity over time. For this purpose, female Wistar rats (n 48) were administered a standard or a cafeteria diet (CAF diet) for 12, 14·5 or 17 weeks and were compared with fa/fa Zucker rats fed a standard diet for 10 weeks. Morphometric variables, plasma biochemical parameters, myeloperoxidase (MPO) activity and reactive oxygen species (ROS) levels in the ileum were assessed, as well as the expressions of proinflammatory genes (TNF-α and inducible nitric oxide synthase (iNOS)) and intestinal permeability genes (zonula occludens-1, claudin-1 and occludin). Both the nutritional model and the genetic obesity model showed increased body weight and metabolic alterations at the final time point. An increase in intestinal ROS production and MPO activity was observed in the gastrointestinal tracts of rats fed a CAF diet but not in the genetic obesity model. TNF-α was overexpressed in the ileum of both CAF diet and fa/fa groups, and ileal inflammation was associated with the degree of obesity and metabolic alterations. Interestingly, the 17-week CAF group and the fa/fa rats exhibited alterations in the expressions of permeability genes. Relevantly, in the hyperlipidic refined sugar diet model of obesity, the responses to chronic energy overload led to time-dependent increases in gut inflammation and oxidative stress.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14752662
    Author's mail: ximena.terra@urv.cat montserrat.pinent@urv.cat mteresa.blay@urv.cat anna.ardevol@urv.cat
    Author identifier: 0000-0003-1043-5844 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-0156-7538
    Record's date: 2023-02-26
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/cafeteria-diet-triggers-intestinal-inflammation-and-oxidative-stress-in-obese-rats/36481830A5146F496471C39333F94D57
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: British Journal Of Nutrition. 117 (2): 218-229
    APA: Gil-Cardoso K, Ginés I, Pinent M, Ardévol A, Terra X, Blay M. (2017). A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats. British Journal Of Nutrition, 117(2), 218-229. DOI: 10.1017/S0007114516004608
    Article's DOI: 10.1017/s0007114516004608
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Proanthocyanidins
    Oxidative stress
    Obesity
    Intestine
    Inflammation
    Gut microbiota
    Gut
    Cafeteria diet
    obesity
    inflammation
    gut
    cafeteria diet
    zo zonula occludens
    tj tight junctions
    rv reverse
    ros reactive oxygen species
    pc principal components
    ocln occludin
    mpo myeloperoxidase
    lepr leptin receptor
    inos isoform of nitric oxide synthase
    homa-ir homeostasis model assessment of insulin resistance
    go genetic obesity
    gi gastrointestinal
    fw forward
    caf diet cafeteria diet
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Engenharias ii
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Administração pública e de empresas, ciências contábeis e turismo
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