Author, as appears in the article.: Siqueira J., Sutton D., Gené J., García D., Wiederhold N., Peterson S., Guarro J.

Department: Ciències Mèdiques Bàsiques

URV's Author/s: García Sánchez, Dania / Gené Díaz, Josepa / Guarro Artigas, Josep / ZEN SIQUEIRA, JOAO PAULO

Keywords: Taxonomy Phenotypic identification Molecular phylogeny Molecular identification Clinical isolates Circumdati section Aspergillus section circumdati Aspergillus Antifungal susceptibility

Abstract: A multilocus phylogenetic study was carried out to assess species identity of a set of 34 clinical isolates from Aspergillus section Circumdati from the USA, and to determine their in vitro antifungal susceptibility against eight antifungal drugs. The genetic markers used were ITS, BenA, CaM and RPB2, and the drugs tested were amphotericin B, itraconazole, posaconazole, voriconazole, anidulafungin, caspofungin, micafungin, and terbinafine. The most common species sampled was A. westerdijkiae (29.4%), followed by a novel species, which was described here as A. pseudosclerotiorum (23.5%). Other species identified were A. sclerotiorum (17.6%), A. ochraceus (8.8%), A. subramanianii (8.8%), and A. insulicola and A. ochraceopetaliformis with two isolates (5.9%) each. The drugs that showed the most potent activity were caspofungin, micafungin, and terbinafine, while amphotericin B showed the least activity. Copyright 2017 American Society for Microbiology.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Microbiology (medical) Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Ensino Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Ciência da computação Biotecnología Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00951137

Author's mail: josep.guarro@urv.cat josepa.gene@urv.cat dania.garcias@urv.cat

Author identifier: 0000-0002-7839-7568 0000-0001-6195-9299 0000-0003-2397-1646

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://jcm.asm.org/content/55/3/947

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Clinical Microbiology. 55 (3): 947-958

APA: Siqueira J., Sutton D., Gené J., García D., Wiederhold N., Peterson S., Guarro J. (2017). Multilocus phylogeny and antifungal susceptibility of Aspergillus section Circumdati from clinical samples and description of A. pseudosclerotiorum sp. nov.. Journal Of Clinical Microbiology, 55(3), 947-958. DOI: 10.1128/JCM.02012-16

Article's DOI: 10.1128/JCM.02012-16

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications