Author, as appears in the article.: Busquets O., Ettcheto M., Pallàs M., Beas-Zarate C., Verdaguer E., Auladell C., Folch J., Camins A.

Department: Bioquímica i Biotecnologia

URV's Author/s: Folch Lopez, Jaume

Keywords: Up-regulation Type 2 diabetes mellitus T2dm, type 2 diabetes mellitus T2dm Ptp1? Ptp1 beta, protein tyrosine phosphatase 1 beta Protein tyrosine phosphatase 1? Obesity Mitogen-activated protein kinase Metabolic syndrome Mechanisms Mapk, mitogen-activated protein kinase Mapk Load, late-onset alzheimer's disease Load Late-onset alzheimer's disease Jnk Insulin-like growth factor-1 Inflammation Igf-1, insulin-like growth factor-1 Igf-1 High-fat diet High calorie diet Hfd, high-fat diet Hfd Hcd, high calorie diet Hcd Expression Energy metabolism Dio, diet-induced obesity Dio Diet-induced obesity Csf, cerebrospinal fluid Csf Cerebrospinal fluid Brain blood barrier Beta-site app-cleaving enzyme 1 Bbb, brain blood barrier Bbb Bace1, beta-site app-cleaving enzyme 1 Bace1 Autophagy Autonomic nervous system Ans. autonomic nervous system Ans Amyloid beta protein Ampk Ampik amp-activated protein kinase Amp-activated protein kinase Alzheimer's disease Ad, alzheimer's disease Ad A? A beta, beta-amyloid ?-amyloid type 2 diabetes mellitus t2dm ptp1? protein tyrosine phosphatase 1? mitogen-activated protein kinase mapk load late-onset alzheimer’s disease insulin-like growth factor-1 igf-1 high-fat diet high calorie diet hfd hcd dio diet-induced obesity csf cerebrospinal fluid brain blood barrier beta-site app-cleaving enzyme 1 bbb bace1 autonomic nervous system ans ampk amp-activated protein kinase alzheimer’s disease ad a?

Abstract: AIMS: The sporadic and late-onset form of Alzheimer's disease (AD) constitutes the most common form of dementia. This non-familiar form could be a consequence of metabolic syndrome, characterized by obesity and the development of a brain-specific insulin resistance known as type III diabetes. This work demonstrates the development of a significant AD-like neuropathology due to these metabolic alterations. METHODS: C57BL/6J mice strain were divided into two groups, one fed with a diet rich in palmitic acid (high-fat diet, HFD) since their weaning until 16 months of age, and another group used as a control with a regular diet. The analyses were carried out in the dentate gyrus area of the hippocampus using a Thioflavin-S stain and immunofluorescence assays. RESULTS: The most significant finding of the present research was that HFD induced the deposition of the βA peptide. Moreover, the diet also caused alterations in different cell processes, such as increased inflammatory reactions that lead to a decrease in the neuronal precursor cells. In addition, the results show that there were also dysregulations in normal autophagy and apoptosis, mechanisms related to βA formation. CONCLUSIONS: The present findings confirm that HFD favors the formation of βA depositions in the brain, a key feature of AD, supporting the metabolic hypothesis of sporadic AD.

Thematic Areas: Medicina iii Medicina ii Medicina i Interdisciplinar Geriatrics & gerontology Educação física Developmental biology Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cell biology Biotecnología Biochemistry & molecular biology Aging

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00476374

Author's mail: jaume.folch@urv.cat

Author identifier: 0000-0002-5051-8858

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0047637416300859?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Mechanisms Of Ageing And Development. 162 38-45

APA: Busquets O., Ettcheto M., Pallàs M., Beas-Zarate C., Verdaguer E., Auladell C., Folch J., Camins A. (2017). Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer's disease. Mechanisms Of Ageing And Development, 162(), 38-45. DOI: 10.1016/j.mad.2016.11.002

Article's DOI: 10.1016/j.mad.2016.11.002

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications