Author, as appears in the article.: Martin-Vicente A, Guarro J, Capilla J

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep

Keywords: Transplant recipient Scopulariopsis brumptii Scopulariopsis brevicaulis Scopulariopsis Scedosporium-prolificans Murine model Lomentospora prolificans Invasive aspergillosis In vitro Fusarium solani Fusarium Filamentous fungi Caspofungin Antifungal drugs Antifungal combinations Amphotericin-b scopulariopsis brevicaulis lomentospora prolificans in vitro fusarium solani antifungal combinations

Abstract: In this study, the in vitro interactions of amphotericin B (AmB), voriconazole (VRC) and anidulafungin (AFG) in double and triple combinations against four species of multiresistant fungi (Fusarium solani, Lomentospora prolificans, Scopulariopsis brevicaulis and Scopulariopsis brumptii) were evaluated. In general, AmB combined with AFG was the most synergistic, especially against F. solani (7/8; 87.5%) when low concentrations of AmB were used, i.e. 0.125-0.5 µg/mL. The least active combination was AmB + VRC, with the lowest percentage of synergy against S. brevicaulis (2/11; 18.2%) and, in general, high concentrations of both antifungals were needed to achieve synergy. The triple combination was also highly synergistic against F. solani and S. brevicaulis, especially when the lowest concentrations of AmB were used, suggesting that use of combined therapies would reduce the toxicity of therapy. The triple combination was more effective than the double combinations in some cases, but not against all strains, suggesting that administration of three drugs is not always useful in the treatment of infections due to multiresistant fungi.

Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Odontología Nutrição Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases General medicine Farmacia Engenharias iii Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 09248579

Author's mail: josep.guarro@urv.cat javier.capilla@urv.cat

Author identifier: 0000-0002-7839-7568 0000-0002-0765-6403

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0924857917300614?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: International Journal Of Antimicrobial Agents. 49 (4): 422-426

APA: Martin-Vicente A, Guarro J, Capilla J (2017). Does a triple combination have better activity than double combinations against multiresistant fungi? Experimental in vitro evaluation.. International Journal Of Antimicrobial Agents, 49(4), 422-426. DOI: 10.1016/j.ijantimicag.2016.12.015

Article's DOI: 10.1016/j.ijantimicag.2016.12.015

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications