Author, as appears in the article.: Cote L.P., Greenberg S., Caprini J.A., Tafur A., Choi C., Muñoz F.J., Skride A., Valero B., Porras J.A., Ciammaichella M., Hernández-Blasco L.M., Monreal M., RIETE Investigators

Department: Medicina i Cirurgia

URV's Author/s: Porras Ledantes, Jose Antonio

Keywords: Upper extremity Recurrences Pulmonary embolism Lower extremity Deep vein thrombosis Catheter Bleeding Anticoagulant therapy recurrences pulmonary embolism lower extremity deep vein thrombosis catheter bleeding anticoagulant therapy

Abstract: © SAGE Publications. Background: The outcome of patients with upper extremity deep vein thrombosis (UEDVT) has not been consistently compared with that in patients with lower extremity deep vein thrombosis (LEDVT). Methods: We used the Registro Informatizado de Enfermedad Trombo Embólica (RIETE) registry to compare the outcomes during the course of anticoagulant therapy in patients with UEDVT versus outcomes in patients with LEDVT. Results: As of August 2015, 37,366 patients with acute DVT had been enrolled in RIETE: 35094 (94%) had LEDVT, 1334 (3.6%) non-catheter related UEDVT (672 unprovoked and 662 provoked) and 938 (2.5%) had catheter-related UEDVT. During the course of anticoagulation, patients with unprovoked UEDVT had a higher rate of DVT recurrences (hazard ratio [HR]: 2.22; 95% CI: 1.37-3.43) and a similar rate of PE recurrences or major bleeding than those with unprovoked LEDVT. Patients with non-catheter-related provoked UEDVT had a similar outcome than those with provoked LEDVT. Among patients with UEDVT, those with non-catheter related unprovoked UEDVT had a lower rate of PE recurrences (HR: 0.06; 95% CI: 0-0.35) and major bleeding (HR: 0.20; 95% CI: 0.08-0.46) than those with catheter-related UEDVT or those with non-catheter related provoked UEDVT (HR: 0.10; 95% CI: 0.004-0.60; and 0.22; 95% CI: 0.08-0.52, respectively). On multivariable analysis, any difference had disappeared. Conclusion: During the course of anticoagulation, patients with UEDVT had a similar outcome than those with LEDVT. Among UEDVT patients, there were some differences according to the presence of catheter or additional risk factors for DVT. These differences disappeared after adjusting for potentially confounding variables.

Thematic Areas: Peripheral vascular disease Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar Hematology General medicine Farmacia Educação física Ciências biológicas ii

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 10760296

Author's mail: joseantonio.porras@urv.cat

Author identifier: 0000-0001-6418-1822

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://journals.sagepub.com/doi/10.1177/1076029616663847

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Clinical And Applied Thrombosis-Hemostasis. 23 (7): 748-754

APA: Cote L.P., Greenberg S., Caprini J.A., Tafur A., Choi C., Muñoz F.J., Skride A., Valero B., Porras J.A., Ciammaichella M., Hernández-Blasco L.M., Monr (2017). Comparisons Between Upper and Lower Extremity Deep Vein Thrombosis: A Review of the RIETE Registry. Clinical And Applied Thrombosis-Hemostasis, 23(7), 748-754. DOI: 10.1177/1076029616663847

Article's DOI: 10.1177/1076029616663847

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications