Author, as appears in the article.: Closa-Monasterolo, Ricardo; Ferre, Natalia; Castillejo-DeVillasante, Gemma; Luque, Veronica; Gispert-Llaurado, Mariona; Zaragoza-Jordana, Marta; Theis, Stephan; Escribano, Joaquin;

Department: Medicina i Cirurgia

URV's Author/s: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Gispert Llauradó, Mariona / Luque Moreno, Verònica

Keywords: Term infants Stool consistency Prebiotics Oligofructose Non-pharmacological treatment Inulin Infant formula Health Epidemiology Double-blind Dietary fiber intake Constipation Children Childhood constipation Adulthood prebiotics non-pharmacological treatment inulin constipation children

Abstract: Constipation is a common disorder in children.The objective of this study is to assess the beneficial effects of a daily supplementation with Orafti® inulin-type fructans in 2-5 year old constipated children.Double-blind, randomised, placebo-controlled parallel group trial where constipated children received two doses of 2?g Orafti® inulin-type fructans (OF:IN) or placebo (maltodextrin) for 6 weeks. Primary outcome was stool consistency. Secondary outcomes were stool frequency and gastrointestinal symptoms.Twenty-two children were included, 17 completed the study protocol (nine and eight for the control and the OF:IN group, respectively). Results showed that Orafti® inulin-type fructans supplemented children had softer stools (p?=?.003). The longitudinal analysis showed no significant changes in controls, whereas supplemented children increased their stool consistency from 2.2 to 2.6 on the modified Bristol scale for children (five items instead of seven) (p?=?.040).Prebiotic inulin-type fructans supplementation improves stool consistency in constipated 2-5-year old children. Clinicaltrials.gov, with number NCT02863848.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition & dietetics Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar General medicine Food science & technology Food science Farmacia Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 09637486

Author's mail: mariona.gispert@urv.cat veronica.luque@urv.cat joaquin.escribano@urv.cat natalia.ferre@urv.cat ricardo.closa@urv.cat

Author identifier: 0000-0003-2615-8175 0000-0002-5041-459X 0000-0002-2838-1525 0000-0002-9963-4163

Record's date: 2023-09-05

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.tandfonline.com/doi/full/10.1080/09637486.2016.1263605

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: International Journal Of Food Sciences And Nutrition. 68 (5): 587-594

APA: Closa-Monasterolo, Ricardo; Ferre, Natalia; Castillejo-DeVillasante, Gemma; Luque, Veronica; Gispert-Llaurado, Mariona; Zaragoza-Jordana, Marta; Theis (2017). The use of inulin-type fructans improves stool consistency in constipated children. A randomised clinical trial: pilot study. International Journal Of Food Sciences And Nutrition, 68(5), 587-594. DOI: 10.1080/09637486.2016.1263605

Article's DOI: 10.1080/09637486.2016.1263605

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications