Author, as appears in the article.: Prosen, Helena; Fontanals, Nuria; Borrull, Francesc; Maria Marce, Rosa;

Department: Química Analítica i Química Orgànica

URV's Author/s: Borrull Ballarín, Francesc / Marcé Recasens, Rosa Maria

Keywords: Spain Solid phase extraction Sewage-sludge Selective determination Samples Psychoactive substances Pharmaceuticals Performance Mixed-mode solid-phase extraction Mixed mode ionic exchange sorbents Liquid chromatography-orbitrap-high resolution mass spectrometry Lc-ms/ms Illicit drugs High-resolution mass spectrometry Environmental water samples Environmental water Drugs of abuse Cathinones high-resolution mass spectrometry environmental water samples drugs of abuse cathinones

Abstract: A method based on liquid chromatography with electrospray ionization high-resolution mass spectrometry (Exactive Orbitrap) combined with solid-phase extraction using a strong cationic exchange mixed-mode sorbent has been developed for the determination of seven drugs of abuse, including two synthetic cathinones, as well as some of their metabolites in environmental water samples. The method provides low detection limits and a high confirmation power thanks to the diagnostic and two fragment ions monitored for each compound in high-resolution mass spectrometry, providing six identification points for each analyte. The clean-up step based on methanol in the extraction step adequately decreased the matrix effect, mainly for river and effluent water, and provided suitable process efficiency. Method detection and quantitation limits for environmental waters were at low nanogram per liter. The method was applied to analyze the samples of influent and effluent wastewater, as well as surface water. Codeine, methadone, and its metabolite were determined in all samples of wastewater and the metabolite of cocaine, benzoylecgonine, was found at the highest concentration.

Thematic Areas: Química Psicología Medicina ii Medicina i Materiais Linguística e literatura Interdisciplinar Filtration and separation Farmacia Engenharias iii Engenharias ii Engenharias i Ciências da religião e teologia Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, analytical Biotecnología Biodiversidade Analytical chemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: francesc.borrull@urv.cat rosamaria.marce@urv.cat

Author identifier: 0000-0003-2718-9336 0000-0002-5667-2899

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.201700287

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Separation Science. 40 (18): 3621-3631

APA: Prosen, Helena; Fontanals, Nuria; Borrull, Francesc; Maria Marce, Rosa; (2017). Determination of seven drugs of abuse and their metabolites in surface and waste water using solid-phase extraction coupled to liquid chromatography-high resolution mass spectrometry. Journal Of Separation Science, 40(18), 3621-3631. DOI: 10.1002/jssc.201700287

Article's DOI: 10.1002/jssc.201700287

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications