Author, as appears in the article.: Cabrera A., Vives M., Molina A., París M., Raga E., Sánchez A., Sabench F., Del Castillo D.

Department: Medicina i Cirurgia

URV's Author/s: Del Castillo Déjardin, Daniel / MOLINA LÓPEZ, ALICIA

Keywords: Sleeve gastrectomy Glucagon Ghrelin Gastric plication Experimental surgery Bariatric surgery glucagon ghrelin gastric plication

Abstract: © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Aim: Laparoscopic gastric plication (LGP) is a bariatric surgical technique based on the anatomical principles of laparoscopic sleeve gastrectomy (LSG), but its effects on the metabolic profile are still uncertain. The aim of our study is to compare the changes in weight, metabolic parameters and gastric histology following intervention by gastric plication (GP) and sleeve gastrectomy (SG) in an experimental model of obesity. Methods: To conduct the study, 32 8-week-old male Sprague-Dawley rats (Charles River®) were fattened by means of a cafeteria diet and randomly assigned to the following experimental groups: group 1: GP (n = 12); group 2: SG (n = 12) and group 3: sham (n = 8). Results: Unlike the SG group, the GP group attained the weight of the sham group at the end of the experiment (week 16). The GP group continued to eat more cafeteria diet than the SG group. In addition, the SG group achieved better glycaemic control than the GP group. Significantly higher plasma ghrelin levels were observed at week 16 in the GP group than in the SG group (2.29 ± 0.5 vs 1.07 ± 0.4, p < 0.05), which also occurred for the glucagon plasmatic levels (62.71 ± 36.2 vs 24.63 ± 9.3, p < 0.05). Conclusions: GP is not as effective as SG and cannot be considered a metabolic surgery due to observed hormonal variations. The animals subjected to a GP continued to have a high appetite for the cafeteria diet unlike the animals submitted to an SG. Hormonal mechanisms possibly related to glucagon and ghrelin may be involved in this metabolic response.

Thematic Areas: Surgery Saúde coletiva Psicología Odontología Nutrition and dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 09608923

Author's mail: danieldel.castillo@urv.cat

Author identifier: 0000-0003-0456-3102 0000-0001-7024-7824

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/submittedVersion

Link to the original source: https://link.springer.com/article/10.1007/s11695-018-3340-7

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Obesity Surgery. 28 (10): 3259-3267

APA: Cabrera A., Vives M., Molina A., París M., Raga E., Sánchez A., Sabench F., Del Castillo D. (2018). Gastric Plication and Sleeve Gastrectomy in an Experimental Model of Obesity: New Insights into Weight Loss, Intake and Metabolic Results. Obesity Surgery, 28(10), 3259-3267. DOI: 10.1007/s11695-018-3340-7

Article's DOI: 10.1007/s11695-018-3340-7

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications