Author, as appears in the article.: Ginés I, Gil-Cardoso K, Serrano J, Casanova-Martí À, Blay M, Pinent M, Ardévol A, Terra X.

Department: Bioquímica i Biotecnologia

e-ISSN: 2072-6643

URV's Author/s: Ardèvol Grau, Anna / CASANOVA MARTÍ, ANGELA / GINÉS MIR, IRIS / Pinent Armengol, Montserrat / Terra Barbadora, Ximena

Keywords: Rat Proanthocyanidins Metabolic syndrome Dose Cafeteria-diet proanthocyanidins metabolic syndrome dose cafeteria-diet

Abstract: Obesity is highly associated with the pathologies included in the concept of the Metabolic Syndrome. Grape-seed proanthocyanins (GSPE) have showed very positive effects against all these metabolic disruptions; however, there is, as yet, no consensus about their effectiveness against an obesogenic challenge, such as a cafeteria diet. We determined the effectiveness of a dose of 500 mg GSPE/kg b.w. (body weight) against the obesogenic effects of a 17-week cafeteria diet, administered as a sub-chronic treatment, 10-15 days before, intermittently and at the end of the diet, in Wistar rats. Body weight, adiposity, indirect calorimetry and plasma parameters were analyzed. GSPE pre-treatment showed a long-lasting effect on body weight and adiposity that was maintained for seven weeks after the last dose. A corrective treatment was administered for the last two weeks of the cafeteria diet intervention; however, it did not effectively correct any of the parameters assessed. The most effective treatment was an intermittent GSPE dosage, administered every second week during the cafeteria diet. This limited body weight gain, adiposity and most lipotoxic effects. Our results support the administration of this GSPE dose, keeping an intermittent interval between dosages longer than every second week, to improve obesogenic disruptions produced by a cafeteria diet.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20726643

Author's mail: ximena.terra@urv.cat montserrat.pinent@urv.cat anna.ardevol@urv.cat

Author identifier: 0000-0003-1043-5844 0000-0003-3550-5378 0000-0003-0156-7538

Record's date: 2023-02-26

Journal volume: 10

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/10/3/315

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 10 (3):

APA: Ginés I, Gil-Cardoso K, Serrano J, Casanova-Martí À, Blay M, Pinent M, Ardévol A, Terra X. (2018). Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats. Nutrients, 10(3), -. DOI: 10.3390/nu10030315

Article's DOI: 10.3390/nu10030315

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

First page: 315

Publication Type: Journal Publications