Author, as appears in the article.: Auguet T, Aragonès G, Colom M, Aguilar C, Martín-Paredero V, Canela N, Ruyra X, Richart C.

Department: Medicina i Cirurgia

URV's Author/s: Aguilar Crespillo, Carmen Isabel / ARAGONÈS BARGALLÓ, GEMMA / Auguet Quintillà, Maria Teresa / Martín Paredero, Vicente / Richart Jurado, Cristobal Manuel

Keywords: Hashtag Etiqueta «#» @uroweb @residentesaeu @infoAeu

Abstract: The aim of the study was to analyse the presence of several metabolites related to atherosclerosis in the plasma of patients with unstable carotid plaque and in the plasma of healthy subjects. Materials and methods We included 20 patients who had undergone carotid endarterectomy and 20 healthy subjects as a control group. All the subjects recruited were male. We used a metabolomic approach with liquid chromatography coupled to mass spectrometry to evaluate plasma metabolite levels in the metabolic pathway involved in the progression of atherosclerotic plaque. Results We observed that circulating levels of 20-HETE were significantly higher in patients with atheroma plaque than in healthy subjects (p = 0.018). No differences were found with regard to the other metabolites analysed. We also conducted a random forest analysis and found that 20-HETE was the main differentiator in the list of selected metabolites. In addition, plasma levels of 20-HETE correlated positively with body mass index (r = 0.427, p = 0.007) and diastolic blood pressure (r = 0.365, p = 0.028). Conclusion This study confirms that of all the molecules studied only 20-HETE is related to carotid plaque. Further studies are needed to compare patients with stable carotid plaque vs. patients with unstable carotid plaque in order to confirm that 20-HETE could be a potential factor related to carotid plaque.

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licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19326203

Author's mail: vicente.martin@urv.cat cristobalmanuel.richart@urv.cat mariateresa.auguet@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat

Author identifier: 0000-0002-2740-5847 0000-0003-0852-6739 0000-0003-0396-6428 0000-0002-4440-562X 0000-0002-4440-562X

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200547

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Plos One. 13 (7): e0200547-

APA: Auguet T, Aragonès G, Colom M, Aguilar C, Martín-Paredero V, Canela N, Ruyra X, Richart C. (2018). Targeted metabolomic approach in men with carotid plaque. Plos One, 13(7), e0200547-. DOI: 10.1371/journal.pone.0200547

Article's DOI: 10.1371/journal.pone.0200547

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications