Author, as appears in the article.: Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Rubió L, Macià A, Solà R.

Department: Medicina i Cirurgia

URV's Author/s: Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / SANDOVAL RAMÍREZ, BERNER ANDRÉE / Solà Alberich, Rosa Maria

Keywords: Tissue bioavailability Phenolic compounds Mechanism-of-action Healthcare Health Anthocyanins Animal studies phenolic compounds mechanism-of-action health anthocyanins animal studies

Abstract: Anthocyanins (ACNs) are promising health-enhancing phenolic compounds. We focus on ACN animal tissue bioavailability to provide an evidentiary link between tissue ACNs and their associated health properties. We performed a systematic review of electronic libraries; 279 results were retrieved, and 13 publications met inclusion criteria. Extracted information included animal model employed, administration route, doses, analysis method, and ACN concentration values in tissues. Total ACN concentrations were detected in mice kidney (2.17 × 105 pmol/g), liver (1.73 × 105 pmol/g), heart (3.6 × 103 pmol/g), and lung (1.16 × 105 pmol/g); and in pig brain (6.08 × 103 pmol/g). ACNs showed a predominance of parent ACNs in long-term experiments versus an ACN metabolite predominance in short-term experiments. ACNs detected in animal tissues, such as cyanidin-3-glucoside, suggest it may have an important role in human health. This information could be useful to determine proper ACN-intake biomarkers in biological samples in futures studies.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Planejamento urbano e regional / demografia Odontología Nutrição Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar General medicine General chemistry General agricultural and biological sciences Food science & technology Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, applied Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Astronomia / física Agriculture, multidisciplinary Agriculture Agricultural and biological sciences (miscellaneous) Agricultural and biological sciences (all)

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00218561

Author's mail: ursula.catalan@urv.cat rosa.sola@urv.cat

Author identifier: 0000-0001-8884-9823 0000-0002-8359-235X

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://pubs.acs.org/doi/10.1021/acs.jafc.8b04014

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Agricultural And Food Chemistry. 66 (44): 11531-11543

APA: Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Rubió L, Macià A, Solà R. (2018). Anthocyanin Tissue Bioavailability in Animals: Possible Implications for Human Health. A Systematic Review. Journal Of Agricultural And Food Chemistry, 66(44), 11531-11543. DOI: 10.1021/acs.jafc.8b04014

Article's DOI: 10.1021/acs.jafc.8b04014

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications