Author, as appears in the article.: Mas-Capdevila, Anna Pons, Zara Aleixandre, Amaya Bravo, Francisca I. Muguerza, Begona

Department: Bioquímica i Biotecnologia

e-ISSN: 2072-6643

URV's Author/s: Bravo Vázquez, Francisca Isabel / Muguerza Marquínez, Maria Begoña / PONS VILA, ZARA

Keywords: Renin Protein hydrolysate Pressure Leg bone protein Hypertension Enzyme-inhibitory peptides Endothelial dysfunction Egg-white By-products Bioavailability Bioactive peptides Angiotensin-converting enzyme Angiotensin Ace-inhibitory activity hypertension endothelial dysfunction bioactive peptides angiotensin-converting enzyme ace-inhibitory activity

Abstract: The antihypertensive properties of different doses of a chicken foot hydrolysate, Hpp11 and the mechanisms involved in this effect were investigated. Spontaneously hypertensive rats (SHR) were administered water, Captopril (50 mg/kg) or Hpp11 at different doses (25, 55 and 85 mg/kg), and the systolic blood pressure (SBP) was recorded. The SBP of normotensive Wistar-Kyoto (WKY) rats administered water or Hpp11 was also recorded. Additionally, plasmatic angiotensin-converting enzyme (ACE) activity was determined in the SHR administered Hpp11. Moreover, the relaxation caused by Hpp11 in isolated aortic rings from Sprague-Dawley rats was evaluated. Hpp11 exhibited antihypertensive activity at doses of 55 and 85 mg/kg, with maximum activity 6 h post-administration. At this time, no differences were found between these doses and Captopril. Initial SBP values of 55 and 85 mg/kg were recovered 24 or 8 h post-administration, respectively, 55 mg/kg being the most effective dose. At this dose, a reduction in the plasmatic ACE activity in the SHR was found. However, Hpp11 did not relax the aortic ring preparations. Therefore, ACE inhibition could be the mechanism underlying Hpp11 antihypertensive effect. Remarkably, Hpp11 did not modify SBP in WKY rats, showing that the decreased SBP effect is specific to the hypertensive state.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: franciscaisabel.bravo@urv.cat begona.muguerza@urv.cat

Author identifier: 0000-0002-6468-3088 0000-0001-7384-8588

Record's date: 2023-02-18

Journal volume: 10

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/10/9/1295

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 10 (9):

APA: Mas-Capdevila, Anna Pons, Zara Aleixandre, Amaya Bravo, Francisca I. Muguerza, Begona (2018). Dose-related antihypertensive properties and the corresponding mechanisms of a chicken foot hydrolysate in hypertensive rats. Nutrients, 10(9), -. DOI: 10.3390/nu10091295

Article's DOI: 10.3390/nu10091295

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications