Author, as appears in the article.: Serena C, Ceperuelo-Mallafré V, Keiran N, Queipo-Ortuño MI, Bernal R, Gomez-Huelgas R, Urpi-Sarda M, Sabater M, Pérez-Brocal V, Andrés-Lacueva C, Moya A, Tinahones FJ, Fernández-Real JM, Vendrell J, Fernández-Veledo S.

Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques

URV's Author/s: Fernandez Veledo, Sonia / Vendrell Ortega, Juan José

Keywords: Sp nov. Serum zonulin Receptor gpr91 Metabolites Mediterranean diet Marker Glucose Emerging role Chain fatty-acids Adipose-tissue

Abstract: © 2018 The Author(s). Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects. Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism. This increase was associated with specific changes in gut microbiota related to succinate metabolism: a higher relative abundance of succinate-producing Prevotellaceae (P) and Veillonellaceae (V), and a lower relative abundance of succinate-consuming Odoribacteraceae (O) and Clostridaceae (C) in obese individuals, with the (P + V/O + C) ratio being a main determinant of plasma succinate. Weight loss intervention decreased (P + V/O + C) ratio coincident with the reduction in circulating succinate. In the spontaneous evolution after good dietary advice, alterations in circulating succinate levels were linked to specific metagenomic signatures associated with carbohydrate metabolism and energy production with independence of body weight change. Our data support the importance of microbe-microbe interactions for the metabolite signature of gut microbiome and uncover succinate as a potential microbiota-derived metabolite related to CVD risk.

Thematic Areas: Microbiology Medicina ii Interdisciplinar Geociências Engenharias iv Engenharias iii Ecology, evolution, behavior and systematics Ecology Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 17517362

Author's mail: sonia.fernandez@urv.cat juanjose.vendrell@urv.cat

Author identifier: 0000-0003-2906-3788 0000-0002-6994-6115

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.nature.com/articles/s41396-018-0068-2

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Isme Journal. 12 (7): 1642-1657

APA: Serena C, Ceperuelo-Mallafré V, Keiran N, Queipo-Ortuño MI, Bernal R, Gomez-Huelgas R, Urpi-Sarda M, Sabater M, Pérez-Brocal V, Andrés-Lacueva C, Moya (2018). Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.. Isme Journal, 12(7), 1642-1657. DOI: 10.1038/s41396-018-0068-2

Article's DOI: 10.1038/s41396-018-0068-2

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications