Articles producció científica> Ciències Mèdiques Bàsiques

Functional effects of the buckwheat iminosugar d-fagomine on rats with diet-induced prediabetes.

  • Identification data

    Identifier: imarina:5132534
    Handle: http://hdl.handle.net/20.500.11797/imarina5132534
  • Authors:

    Ramos-Romero S, Hereu M, Atienza L, Casas J, Taltavull N, Romeu M, Amézqueta S, Dasilva G, Medina I, Torres JL
  • Others:

    Author, as appears in the article.: Ramos-Romero S, Hereu M, Atienza L, Casas J, Taltavull N, Romeu M, Amézqueta S, Dasilva G, Medina I, Torres JL
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Romeu Ferran, Marta / Taltavull Anglada, Núria
    Keywords: Weight Polyunsaturated fatty-acids Obesity Microbiota Mice Mechanisms Insulin-resistance Inflammation Induced obesity Iminosugars Iminocyclitol Gut microbiota Endotoxemia Diabetes microbiota inflammation iminosugars iminocyclitol diabetes
    Abstract: The goals of this work are to test if d-fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat-induced prediabetic state in a rat model and to explore possible mechanisms behind its functional action.Wistar Kyoto rats were fed a high-fat diet supplemented with d-fagomine (or not, for comparison) or a standard diet (controls) for 24 weeks. The variables measured were fasting blood glucose and insulin levels; glucose tolerance; diacylglycerols as intracellular mediators of insulin resistance in adipose tissue (AT), liver, and muscle; inflammation markers (plasma IL-6 and leptin, and liver and AT histology markers); eicosanoids from arachidonic acid as lipid mediators of inflammation; and the populations of Bacteroidetes, Firmicutes, Enterobacteriales, and Bifidobacteriales in feces. It was found that d-fagomine reduces fat-induced impaired glucose tolerance, inflammation markers, and mediators (hepatic microgranulomas and lobular inflammation, plasma IL-6, prostaglandin E2 , and leukotriene B4 ) while attenuating the changes in the populations of Enterobacteriales and Bifidobacteriales.d-Fagomine delays the development of a fat-induced prediabetic state in rats by reducing low-grade inflammation. We suggest that the anti-inflammatory effect of d-fagomine may be linked to a reduction in fat-induced overpopulation of minor gut bacteria.© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16134125
    Author's mail: nuria.taltavull@urv.cat marta.romeu@urv.cat
    Author identifier: 0000-0002-3340-2650 0000-0002-2131-1858
    Record's date: 2023-02-18
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201800373
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Molecular Nutrition & Food Research. 62 (16): e1800373-
    APA: Ramos-Romero S, Hereu M, Atienza L, Casas J, Taltavull N, Romeu M, Amézqueta S, Dasilva G, Medina I, Torres JL (2018). Functional effects of the buckwheat iminosugar d-fagomine on rats with diet-induced prediabetes.. Molecular Nutrition & Food Research, 62(16), e1800373-. DOI: 10.1002/mnfr.201800373
    Article's DOI: 10.1002/mnfr.201800373
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Biotechnology,Food Science,Food Science & Technology
    Weight
    Polyunsaturated fatty-acids
    Obesity
    Microbiota
    Mice
    Mechanisms
    Insulin-resistance
    Inflammation
    Induced obesity
    Iminosugars
    Iminocyclitol
    Gut microbiota
    Endotoxemia
    Diabetes
    microbiota
    inflammation
    iminosugars
    iminocyclitol
    diabetes
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física
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