Author, as appears in the article.: Thomson P, López-Fernández L, Guarro J, Capilla J

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep

Keywords: Yeast infections Voriconazole Virulence Triazole Therapy Spp. Rhodotorula mucilaginosa Posaconazole Pharmacodynamics Model Fungemia Candidiasis Antifungal susceptibility therapy rhodotorula mucilaginosa antifungal susceptibility

Abstract: Rhodotorula infections have emerged in recent years causing mainly fungemia associated to high mortality. We have evaluated the in vitro activity of nine antifungal drugs against four clinical strains of Rhodotorula mucilaginosa, being amphotericin B, voriconazole and posaconazole the most active compounds. The experimental virulence of this fungus and the efficacy of the three mentioned drugs were evaluated in disseminated infections in neutropenic mice. Infection resulted in a high fungal load in all the organs studied without evident particular tropism. All treated animals showed reduced burden respect to the control in a strain dependent manner being voriconazole slightly superior to posaconazole and amphotericin B.

Thematic Areas: Saúde coletiva Química Odontología Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases Farmacia Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 07328893

Author's mail: josep.guarro@urv.cat javier.capilla@urv.cat

Author identifier: 0000-0002-7839-7568 0000-0002-0765-6403

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0732889317301827

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Diagnostic Microbiology And Infectious Disease. 89 (1): 47-51

APA: Thomson P, López-Fernández L, Guarro J, Capilla J (2017). Virulence and antifungal therapy of murine disseminated infection by Rhodotorula mucilaginosa. Diagnostic Microbiology And Infectious Disease, 89(1), 47-51. DOI: 10.1016/j.diagmicrobio.2017.06.005

Article's DOI: 10.1016/j.diagmicrobio.2017.06.005

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications